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PMID: 26389842 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep.

Nature neuroscience ·Vol. 18 ·No. 11 ·2015-11-00 ·Pages 1679-1686

Staresina BP, Bergmann TO, Bonnefond M, van der Meij R, Jensen O, Deuker L, Elger CE, Axmacher N, Fell J

Abstract

During systems-level consolidation, mnemonic representations initially reliant on the hippocampus are thought to migrate to neocortical sites for more permanent storage, with an eminent role of sleep for facilitating this information transfer. Mechanistically, consolidation processes have been hypothesized to rely on systematic interactions between the three cardinal neuronal oscillations characterizing non-rapid eye movement (NREM) sleep. Under global control of de- and hyperpolarizing slow oscillations (SOs), sleep spindles may cluster hippocampal ripples for a precisely timed transfer of local information to the neocortex. We used direct intracranial electroencephalogram recordings from human epilepsy patients during natural sleep to test the assumption that SOs, spindles and ripples are functionally coupled in the hippocampus. Employing cross-frequency phase-amplitude coupling analyses, we found that spindles were modulated by the up-state of SOs. Notably, spindles were found to in turn cluster ripples in their troughs, providing fine-tuned temporal frames for the hypothesized transfer of hippocampal memory traces.

MeSH Terms
Adult Electroencephalography/methods Epilepsy/physiopathology Female Hippocampus/physiology Humans Male Memory/physiology Neocortex/physiology Sleep/physiology Young Adult
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Staresina Bernhard P
School of Psychology, University of Birmingham, Birmingham, UK. | MRC Cognition and Brain Sciences Unit, Cambridge, UK.
Bergmann Til Ole
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, NL. | Institute of Psychology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Bonnefond Mathilde
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, NL.
van der Meij Roemer
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, NL.
Jensen Ole
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, NL.
Deuker Lorena
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, NL.
Elger Christian E
Department of Epileptology, University of Bonn, Bonn, Germany.
Axmacher Nikolai
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. | Department of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Germany.
Fell Juergen
Department of Epileptology, University of Bonn, Bonn, Germany.
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Article Info
Journal
Nature neuroscience
Abbr.
Nat Neurosci
ISSN
1546-1726
DOI
10.1038/nn.4119
Published
2015-11-00
Epub
2015-00-21
Pages
1679-1686
Language
English
Region
United States
NLM ID
9809671
PMCID
PMC4625581
Subset
IM
Grants
Wellcome Trust · 089049 · United Kingdom
Wellcome Trust · WT089049AIA · United Kingdom
External Links
PubMed source DOI: 10.1038/nn.4119 PMC Full Text View journal details
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