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PMID: 2645211 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Association of Campylobacter pylori with induced expression of class II transplantation antigens on gastric epithelial cells.

Infection and immunity ·Vol. 57 ·No. 3 ·1989-03-00 ·Pages 827-32

Engstrand L, Scheynius A, Påhlson C, Grimelius L, Schwan A, Gustavsson S

Abstract

Campylobacter pylori was identified with immunoperoxidase staining and a mouse monoclonal antibody directed against C. pylori in gastric biopsy specimens from 24 patients with gastritis. C. pylori was not found in gastric biopsy specimens from six subjects with histologically normal mucosa. The monoclonal antibody, which was reactive with a surface protein of approximately 20 kilodaltons, was found to be specific for C. pylori, and the immunoperoxidase staining proved to be more sensitive and rapid than culture in detecting the organism. In the tissue specimens where C. pylori was detected with the monoclonal antibody, there was a strong expression of class II transplantation antigens on the epithelial cells and an increased number of T lymphocytes. These findings indicate that C. pylori may initiate local immune responses.

MeSH Terms
Antibodies, Monoclonal Antigens, Bacterial/immunology Antigens, Differentiation, T-Lymphocyte/analysis Bacterial Proteins/immunology Campylobacter/immunology,pathogenicity Epithelium/immunology Gastric Mucosa/immunology Gastritis/immunology,microbiology HLA-D Antigens/immunology Humans Immunoenzyme Techniques Middle Aged Molecular Weight T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal Antigens, Bacterial Antigens, Differentiation, T-Lymphocyte Bacterial Proteins HLA-D Antigens
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Engstrand L
Department of Clinical Bacteriology, University Hospital, Uppsala, Sweden.
Scheynius A
Påhlson C
Grimelius L
Schwan A
Gustavsson S
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.57.3.827-832.1989
Published
1989-03-00
Pages
827-32
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC313184
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.57.3.827-832.1989 PMC Full Text View journal details
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