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PMID: 26497145 Published · epublish English Journal Article Research Support, Non-U.S. Gov't

Turnover of Sex Chromosomes in Celebensis Group Medaka Fishes.

G3 (Bethesda, Md.) ·Vol. 5 ·No. 12 ·2015-10-23 ·Pages 2685-91

Myosho T, Takehana Y, Hamaguchi S, Sakaizumi M

Abstract

Sex chromosomes and the sex-determining (SD) gene are variable in vertebrates. In particular, medaka fishes in the genus Oryzias show an extremely large diversity in sex chromosomes and the SD gene, providing a good model to study the evolutionary process by which they turnover. Here, we investigated the sex determination system and sex chromosomes in six celebensis group species. Our sex-linkage analysis demonstrated that all species had an XX-XY sex determination system, and that the Oryzias marmoratus and O. profundicola sex chromosomes were homologous to O. latipes linkage group (LG) 10, while those of the other four species, O. celebensis, O. matanensis, O. wolasi, and O. woworae, were homologous to O. latipes LG 24. The phylogenetic relationship suggested a turnover of the sex chromosomes from O. latipes LG 24 to LG 10 within this group. Six sex-linkage maps showed that the former two and the latter four species shared a common SD locus, respectively, suggesting that the LG 24 acquired the SD function in a common ancestor of the celebensis group, and that the LG 10 SD function appeared in a common ancestor of O. marmoratus and O. profundicola after the divergence of O. matanensis. Additionally, fine mapping and association analysis in the former two species revealed that Sox3 on the Y chromosome is a prime candidate for the SD gene, and that the Y-specific 430-bp insertion might be involved in its SD function.

Keywords
Sox convergent evolution genetics of sex medaka sex chromosome sex-determining gene
MeSH Terms
Animals Chromosome Mapping Crosses, Genetic Female Genetic Linkage Genetic Markers Inheritance Patterns Male Mutation Oryzias/classification,genetics Phylogeny Sex Chromosomes Sex Determination Processes/genetics
Chemicals
Genetic Markers
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Myosho Taijun
Institute of Science and Technology, Niigata University, Niigata 950-2181, Japan [email protected].
Takehana Yusuke
Laboratory of Bioresources, National Institute for Basic Biology, Okazaki 444-8585, Japan.
Hamaguchi Satoshi
Institute of Science and Technology, Niigata University, Niigata 950-2181, Japan.
Sakaizumi Mitsuru
Institute of Science and Technology, Niigata University, Niigata 950-2181, Japan.
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Article Info
Journal
G3 (Bethesda, Md.)
Abbr.
G3 (Bethesda)
ISSN
2160-1836
DOI
10.1534/g3.115.021543
Email
[email protected]
Published
2015-10-23
Epub
2015-00-23
Pages
2685-91
Language
English
Region
England
NLM ID
101566598
PMCID
PMC4683641
Subset
IM
Databases
GENBANK
LC037173, LC037174, LC037175, LC037176
External Links
PubMed source DOI: 10.1534/g3.115.021543 PMC Full Text View journal details
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