Acute inflammatory effects of a monocyte-derived neutrophil-activating peptide in rabbit skin.

Immunology ·Vol. 67 ·No. 2 ·1989-06-00 ·Pages 181-3

Foster SJ, Aked DM, Schröder JM, Christophers E

Abstract

The inflammatory effects of a monocyte-derived neutrophil-activating peptide (MONAP), purified to homogeneity from lipopolysaccharide-stimulated human peripheral blood monocytes, have been evaluated in rabbit skin. Intradermal injection of MONAP alone caused a mild infiltration of polymorphonuclear leucocytes (PMNL) but did not induce any change in plasma extravasation. When combined with prostaglandin E2(PGE2), MONAP caused a marked and synergistic increase in PMNL infiltration and plasma extravasation into the injected skin sites. The increase in vascular permeability induced by MONAP depended on the presence of circulating PMNL. MONAP is a novel cytokine with pro-inflammatory properties and may have physiological and pathophysiological roles in health and disease.

MeSH Terms

Animals Capillary Permeability Chemotactic Factors/administration & dosage Chemotaxis, Leukocyte Dinoprostone/administration & dosage Female Humans Injections, Intradermal Interleukin-8 Leukocyte Count Monocytes/immunology Neutrophils/pathology Rabbits Skin/blood supply,immunology,pathology

Chemicals

Chemotactic Factors Interleukin-8 Dinoprostone

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Foster S J

ICI Pharmaceuticals, Cheshire U.K.

Aked D M

Schröder J M

Christophers E

References (12)

12 references, click to expand

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1989-06-00

Pages

181-3

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1385254

Subset

External Links

PubMed source PMC Full Text View journal details

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Acute inflammatory effects of a monocyte-derived neutrophil-activating peptide in rabbit skin.

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