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PMID: 266735 Published · ppublish English Journal Article

Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 5 ·1977-05-00 ·Pages 2135-9

Rivière Y, Gresser I, Guillon JC, Tovey MG

Abstract

Inoculation of newborn mice with lymphocytic chloriomeningitis (LCM) virus resulted in decreased weight gain, liver cell necrosis, and death. Injection of potent sheep immunoglobulin against mouse interferon markedly inhibited these manifestations of LCM virus disease despite the fact that these treated mice had 100-fold more LCM virus in their serum. We conclude that interferon induced by LCM virus is responsible in large part for the syndrome of growth inhibition, liver cell necrosis, and death observed in LCM virus-infected suckling mice.

MeSH Terms
Animals Animals, Newborn/physiology Antibodies Blood/microbiology Growth Immunotherapy Interferons/blood,immunology Liver/pathology Lymphocytic Choriomeningitis/pathology,physiopathology,therapy Lymphocytic choriomeningitis virus/isolation & purification Mice
Chemicals
Antibodies Interferons
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rivière Y
Gresser I
Guillon J C
Tovey M G
References (30)
30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.5.2135
Published
1977-05-00
Pages
2135-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431090
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.5.2135 PMC Full Text View journal details
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