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PMID: 27066274 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Parietal Fast Sleep Spindle Density Decrease in Alzheimer's Disease and Amnesic Mild Cognitive Impairment.

Neural plasticity ·Vol. 2016 ·2016-00-00 ·Pages 8376108

Gorgoni M, Lauri G, Truglia I, Cordone S, Sarasso S, Scarpelli S, Mangiaruga A, D'Atri A, Tempesta D, Ferrara M, Marra C, Rossini PM, De Gennaro L

Abstract

Several studies have identified two types of sleep spindles: fast (13-15 Hz) centroparietal and slow (11-13 Hz) frontal spindles. Alterations in spindle activity have been observed in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). Only few studies have separately assessed fast and slow spindles in these patients showing a reduction of fast spindle count, but the possible local specificity of this phenomenon and its relation to cognitive decline severity are not clear. Moreover, fast and slow spindle density have never been assessed in AD/MCI. We have assessed fast and slow spindles in 15 AD patients, 15 amnesic MCI patients, and 15 healthy elderly controls (HC). Participants underwent baseline polysomnographic recording (19 cortical derivations). Spindles during nonrapid eye movements sleep were automatically detected, and spindle densities of the three groups were compared in the derivations where fast and slow spindles exhibited their maximum expression (parietal and frontal, resp.). AD and MCI patients showed a significant parietal fast spindle density decrease, positively correlated with Minimental State Examination scores. Our results suggest that AD-related changes in spindle density are specific for frequency and location, are related to cognitive decline severity, and may have an early onset in the pathology development.

MeSH Terms
Aged Alzheimer Disease/physiopathology,psychology Amnesia/physiopathology,psychology Attention/physiology Brain/physiopathology Brain Waves/physiology Cognition/physiology Cognitive Dysfunction/physiopathology,psychology Electroencephalography Female Humans Male Neuropsychological Tests Sleep/physiology
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Gorgoni Maurizio
Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
Lauri Giulia
Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
Truglia Ilaria
Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
Cordone Susanna
Department of Physiology and Pharmacology, "Sapienza" University of Rome, 00185 Rome, Italy.
Sarasso Simone
Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, 20157 Milan, Italy.
Scarpelli Serena
Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
Mangiaruga Anastasia
Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
D'Atri Aurora
Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
Tempesta Daniela
Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Ferrara Michele
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 Coppito, Italy.
Marra Camillo
Institute of Neurology, Catholic University of The Sacred Heart, 00168 Rome, Italy.
Rossini Paolo Maria
Institute of Neurology, Catholic University of The Sacred Heart, 00168 Rome, Italy; IRCCS San Raffaele Pisana, 00163 Rome, Italy.
De Gennaro Luigi
Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
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Article Info
Journal
Neural plasticity
Abbr.
Neural Plast
ISSN
1687-5443
DOI
10.1155/2016/8376108
Published
2016-00-00
Epub
2016-00-15
Pages
8376108
Language
English
Region
United States
NLM ID
100883417
PMCID
PMC4811201
Subset
IM
External Links
PubMed source DOI: 10.1155/2016/8376108 PMC Full Text View journal details
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