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PMID: 27095192 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees.

Nucleic acids research ·Vol. 44 ·No. W1 ·2016-00-08 ·Pages W242-5

Letunic I, Bork P

Abstract

Interactive Tree Of Life (http://itol.embl.de) is a web-based tool for the display, manipulation and annotation of phylogenetic trees. It is freely available and open to everyone. The current version was completely redesigned and rewritten, utilizing current web technologies for speedy and streamlined processing. Numerous new features were introduced and several new data types are now supported. Trees with up to 100,000 leaves can now be efficiently displayed. Full interactive control over precise positioning of various annotation features and an unlimited number of datasets allow the easy creation of complex tree visualizations. iTOL 3 is the first tool which supports direct visualization of the recently proposed phylogenetic placements format. Finally, iTOL's account system has been redesigned to simplify the management of trees in user-defined workspaces and projects, as it is heavily used and currently handles already more than 500,000 trees from more than 10,000 individual users.

MeSH Terms
Algorithms Animals Archaea/classification,genetics Bacteria/classification,genetics Biological Evolution Computer Graphics Datasets as Topic Eukaryota/classification,genetics Humans Information Storage and Retrieval Internet Phylogeny User-Computer Interface
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Letunic Ivica ORCID
Biobyte solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany [email protected].
Bork Peer
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany Max Delbrück Centre for Molecular Medicine, 13125 Berlin, Germany Department of Bioinformatics, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
References (15)
15 references, click to expand
  1. TreeDyn: towards dynamic graphics and annotations for analyses of trees.
    BMC Bioinformatics. 2006 Oct 10;7:439 PMID: 17032440
  2. Inferring evolutionary trees with PAUP*.
    Curr Protoc Bioinformatics. 2003 Feb;Chapter 6:Unit 6.4 PMID: 18428704
  3. PhyloWidget: web-based visualizations for the tree of life.
    Bioinformatics. 2008 Jul 15;24(14):1641-2 PMID: 18487241
  4. Dendroscope 3: an interactive tool for rooted phylogenetic trees and networks.
    Syst Biol. 2012 Dec 1;61(6):1061-7 PMID: 22780991
  5. Toward automatic reconstruction of a highly resolved tree of life.
    Science. 2006 Mar 3;311(5765):1283-7 PMID: 16513982
  6. A format for phylogenetic placements.
    PLoS One. 2012;7(2):e31009 PMID: 22383988
  7. Visualization of multiple alignments, phylogenies and gene family evolution.
    Nat Methods. 2010 Mar;7(3 Suppl):S16-25 PMID: 20195253
  8. ATV: display and manipulation of annotated phylogenetic trees.
    Bioinformatics. 2001 Apr;17(4):383-4 PMID: 11301314
  9. Compact graphical representation of phylogenetic data and metadata with GraPhlAn.
    PeerJ. 2015 Jun 18;3:e1029 PMID: 26157614
  10. Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy.
    Nucleic Acids Res. 2011 Jul;39(Web Server issue):W475-8 PMID: 21470960
  11. Performance, accuracy, and Web server for evolutionary placement of short sequence reads under maximum likelihood.
    Syst Biol. 2011 May;60(3):291-302 PMID: 21436105
  12. ETE: a python Environment for Tree Exploration.
    BMC Bioinformatics. 2010 Jan 13;11:24 PMID: 20070885
  13. phyloXML: XML for evolutionary biology and comparative genomics.
    BMC Bioinformatics. 2009 Oct 27;10:356 PMID: 19860910
  14. pplacer: linear time maximum-likelihood and Bayesian phylogenetic placement of sequences onto a fixed reference tree.
    BMC Bioinformatics. 2010 Oct 30;11:538 PMID: 21034504
  15. Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation.
    Bioinformatics. 2007 Jan 1;23(1):127-8 PMID: 17050570
Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gkw290
Email
[email protected]
Published
2016-00-08
Epub
2016-00-19
Pages
W242-5
Language
English
Region
England
NLM ID
0411011
PMCID
PMC4987883
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/gkw290 PMC Full Text View journal details
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