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PMID: 271959 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Retinoic acid (vitamin A acid) induced transcriptional control of interferon production.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 12 ·1977-12-00 ·Pages 5382-6

Blalock JE, Gifford GE

Abstract

The production of interferon was used to study the site and mechanism of action of retinoic acid (vitamin A). The data are consistent with a site of action at the gene level, because it appears that interferon production is blocked at the transcriptional step by a retinoic acid-induced protein. (i) The effect of retinoic acid is probably on an early cellular function associated with interferon production rather than an effect on the inducer [virus or poly(I).poly(C)]. (ii) The suppression of interferon production by retinoic acid is blocked by cycloheximide, indicating that a newly synthesized protein (repressor) mediates the suppression. (iii) When allowances are made for the time required for the synthesis of the retinoic acid-induced protein, the time course of retinoic acid suppression of interferon production is superimposable on the time course of actinomycin D suppression because the slopes are parallel. These data provide evidence for transcriptional control of a specific protein (interferon) by retinoic acid. Additionally, they support the existence of transcriptional control of interferon production after addition of inducer.

MeSH Terms
Cycloheximide/pharmacology Dactinomycin/pharmacology Interferon Inducers/pharmacology Interferons/biosynthesis,genetics Kinetics L Cells RNA, Messenger/biosynthesis Transcription, Genetic/drug effects Tretinoin/pharmacology Vitamin A/analogs & derivatives
Chemicals
Interferon Inducers RNA, Messenger Vitamin A Dactinomycin Tretinoin Interferons Cycloheximide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Blalock J E
Gifford G E
References (22)
22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.12.5382
Published
1977-12-00
Pages
5382-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC431728
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.12.5382 PMC Full Text View journal details
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