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PMID: 272660 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Evidence that tumor antigens enhance tumor growth in vivo by interacting with a radiosensitive (suppressor?) cell population.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 1 ·1978-01-00 ·Pages 436-40

Hellström KE, Hellström I

Abstract

The growth of a small number of cells from each of two chemically induced BALB/c sarcomas was enhanced when x-irradiated (15,000 rads) cells of the same sarcoma were mixed with the tumor inoculum. This enhancement did not occur if the recipients had been given a total body x-irradiation of 450 rads. Tumor neutralization (Winn) tests showed that tumor cells irradiated in vitro enhanced tumor growth only in the presence of radiosensitive cells present in the spleens of both nonimmune and tumor-bearing mice. On the basis of these findings we postulate that tumor antigen blocks effective tumor immunity by a mechanism that involves a suppressor cell population.

MeSH Terms
Animals Antigens, Neoplasm Female Immunity, Cellular/radiation effects Immunization Immunosuppression Therapy Mice Sarcoma, Experimental/immunology,pathology,physiopathology Spleen/immunology X-Rays
Chemicals
Antigens, Neoplasm
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hellström K E
Hellström I
References (26)
26 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.1.436
Published
1978-01-00
Pages
436-40
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC411264
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.1.436 PMC Full Text View journal details
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