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PMID: 273256 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Assignment of genes to regions of mouse chromosomes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 2 ·1978-02-00 ·Pages 946-50

Eicher EM, Washburn LL

Abstract

A genetic mapping procedure, called the duplication-deficiency method, is described. This method permits the genetic location of a translocation to be determined within a linkage group without the use of recombination. By utilizing the duplication-deficiency method to define the genetic breakpoints for a series of translocations involving a given chromosome and integrating this information with their cytological breakpoints, obtained by Giemsa banding, a genetic map of the chromosomes is constructed whereby groups of loci are assigned to banded regions. Duplication-deficiency mapping and Giemsa banding analysis of the T(X;7)1Ct and T(7;19)145H translocations together with information from the c25H deletion have permitted mouse chromosome 7 to be divided into six and chromosome 19 into two definable genetic regions.

MeSH Terms
Animals Azure Stains Chromosome Mapping/methods Genetic Linkage Mice Translocation, Genetic
Chemicals
Azure Stains
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Eicher E M
Washburn L L
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26 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.2.946
Published
1978-02-00
Pages
946-50
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC411375
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.2.946 PMC Full Text View journal details
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