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PMID: 2734313 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Quantifying the infectivity of human immunodeficiency virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 12 ·1989-06-00 ·Pages 4644-8

Layne SP, Spouge JL, Dembo M

Abstract

We have developed a mathematical model that quantifies lymphocyte infection by human immunodeficiency virus (HIV) and lymphocyte protection by blocking agents such as soluble CD4. We use this model to suggest standardized parameters for quantifying viral infectivity and to suggest techniques for calculating these parameters from well-mixed infectivity assays. We discuss the implications of the model for our understanding of the infectious process and virulence of HIV in vivo.

MeSH Terms
Acquired Immunodeficiency Syndrome/immunology HIV/immunology,pathogenicity Humans Lymphocytes/immunology,microbiology Models, Statistical Probability
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Layne S P
Theoretical Division, Los Alamos National Laboratory, NM 87545.
Spouge J L
Dembo M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.12.4644
Published
1989-06-00
Pages
4644-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC287327
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.86.12.4644 PMC Full Text View journal details
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