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PMID: 3401118 Published · ppublish English Journal Article

The organization of the envelope projections on the surface of HIV.

Archives of virology ·Vol. 100 ·No. 3-4 ·1988-00-00 ·Pages 255-66

Ozel M, Pauli G, Gelderblom HR

Abstract

The organization of envelope projections (knobs) of four different isolates of the human immunodeficiency virus types 1 and 2 (HIV-1 and -2) was studied using surface replica and thin section electron microscopy (EM) in combination with rotational image enhancement. All HIV strains show an identical organization of knobs on the virus envelope. The surface of an "ideal", well-preserved HIV particle is studded with 72 knobs arranged in a T = 7 laevo symmetry. The role of the p 17 protein, which is coating the inner leaflet of the viral envelope, is discussed as a matrix protein functioning as a scaffold for the envelope and its projections during morphogenesis as well as with mature virions.

MeSH Terms
HIV/ultrastructure Microscopy, Electron Retroviridae Proteins/physiology Viral Matrix Proteins/physiology Virion/ultrastructure
Chemicals
Retroviridae Proteins Viral Matrix Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ozel M
Robert Koch-Institut des Bundesgesundheitsamtes, Berlin.
Pauli G
Gelderblom H R
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01487688
Published
1988-00-00
Pages
255-66
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01487688 View journal details
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