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PMID: 27642 Published · ppublish English Journal Article

Biotin. Its place in evolution.

Journal of molecular evolution ·Vol. 11 ·No. 2 ·1978-06-20 ·Pages 171-87

Visser CM, Kellogg RM

Abstract

In the previous article we try to give an explanation for the success of models of enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally new sort of problem to bioorganic chemistry; this problem requires consideration both of the origin of life and subsequent evolution in any attempt to understand the anomalies offered by this cofactor.

MeSH Terms
Acetyl-CoA Carboxylase/metabolism Biological Evolution Biotin/genetics,physiology Carbon Dioxide/metabolism Catalysis Enzymes/genetics Origin of Life RNA/genetics Structure-Activity Relationship Urea/metabolism
Chemicals
Enzymes Carbon Dioxide RNA Biotin Urea Acetyl-CoA Carboxylase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Visser C M
Kellogg R M
References (40)
40 references, click to expand
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Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
Published
1978-06-20
Pages
171-87
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
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