T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis.

Immunogenetics ·Vol. 29 ·No. 2 ·1989-00-00 ·Pages 75-9

Boon T, Van Pel A

Abstract

It is now widely accepted that cytolytic T cells recognize their antigens in the form of small peptides bound to major histocompatibility complex molecules at the surface of the target cells. We present here the hypothesis that, when these antigenic peptides are derived from the cellular genome, they are not degradation products of cellular proteins but can be generated directly by the autonomous transcription and translation of short subgenic regions that we propose to name "peptons". We discuss some consequences of the notion that antigenic peptides can be produced in the absence of synthesis of messenger RNA and protein from the corresponding genes.

MeSH Terms

Animals Antigens/genetics,immunology Models, Biological Promoter Regions, Genetic Protein Biosynthesis T-Lymphocytes, Cytotoxic/immunology Transcription, Genetic

Chemicals

Antigens

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Boon T

Ludwig Institute for Cancer Research, Brussels, Belgium.

Van Pel A

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27 references, click to expand

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Article Info

Journal

Immunogenetics

Abbr.

Immunogenetics

ISSN

0093-7711

DOI

10.1007/BF00395854

Published

1989-00-00

Pages

75-9

Language

English

Region

United States

NLM ID

0420404

Subset

Corrections

CommentIn

PMID: 1713189

External Links

PubMed source DOI: 10.1007/BF00395854 View journal details

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T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis.

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