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PMID: 2813358 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

3' noncoding region of phosphoenolpyruvate carboxykinase mRNA contains a glucocorticoid-responsive mRNA-stabilizing element.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 20 ·1989-10-00 ·Pages 7800-4

Petersen DD, Koch SR, Granner DK

Abstract

The stabilization of phosphoenolpyruvate carboxykinase mRNA by glucocorticoids appears to result from the interaction of an induced factor with an RNA element located in the 3' noncoding sequence of the mRNA. This element can confer glucocorticoid-dependent stabilization upon a heterologous mRNA, and thus strategies developed to investigate the control of mRNA transcription can now be applied to the analysis of hormone-regulated mRNA stabilization.

MeSH Terms
Animals Cell Line Chloramphenicol O-Acetyltransferase/genetics Cloning, Molecular Dexamethasone/pharmacology Genes/drug effects Kinetics Liver Neoplasms, Experimental Phosphoenolpyruvate Carboxykinase (GTP)/genetics Plasmids RNA, Messenger/drug effects,genetics,metabolism Rats Transcription, Genetic/drug effects Transfection
Chemicals
RNA, Messenger Dexamethasone Chloramphenicol O-Acetyltransferase Phosphoenolpyruvate Carboxykinase (GTP)
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Petersen D D
Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232.
Koch S R
Granner D K
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31 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.20.7800
Published
1989-10-00
Pages
7800-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC298158
Subset
IM
Grants
NIDDK NIH HHS · DK20593 · United States
NIDDK NIH HHS · DK35107 · United States
External Links
PubMed source DOI: 10.1073/pnas.86.20.7800 PMC Full Text View journal details
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