Recent insertion of an Alu sequence in the beta-globin gene cluster of the gorilla.
We present the nucleotide sequence of a new Alu family member that lies between the delta- and beta-globin genes in gorilla DNA. The sequence exhibits 91% similarity with a consensus sequence of the Alu family. It is flanked by a perfect repetition of a 16-nucleotide target sequence and terminates with 24 adenylic residues. As this sequence is absent at this locus in other primate DNAs, its insertion occurred less than 8 million years ago, thus supporting the idea that Alu sequences are still mobile elements in the hominoid genome.
21 references, click to expand
-
Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene.Proc Natl Acad Sci U S A. 1983 Aug;80(16):5012-6 PMID: 6308666
-
A mouse type 2 Alu sequence (M2) is mobile in the genome.Nature. 1983 Jan 6;301(5895):87-9 PMID: 6296687
-
"Nonrandom" DNA sequence analysis in bacteriophage M13 by the dideoxy chain-termination method.Proc Natl Acad Sci U S A. 1982 Jul;79(14):4298-302 PMID: 6956859
-
Insertion of an Alu SINE in the human homologue of the Mlvi-2 locus.Nucleic Acids Res. 1985 Dec 9;13(23):8379-87 PMID: 3001638
-
Detection of specific sequences among DNA fragments separated by gel electrophoresis.J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
-
The Alu family of dispersed repetitive sequences.Science. 1982 Jun 4;216(4550):1065-70 PMID: 6281889
-
DNA sequencing with chain-terminating inhibitors.Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
-
The phylogeny of the hominoid primates, as indicated by DNA-DNA hybridization.J Mol Evol. 1984;20(1):2-15 PMID: 6429338
-
Evolution of the beta-globin gene cluster in man and the primates.J Mol Biol. 1981 Jul 5;149(3):319-36 PMID: 6273584
-
Nucleotide sequence analysis of the delta beta-globin gene region in humans.J Biol Chem. 1983 Oct 10;258(19):11599-609 PMID: 6311816
-
A molecular solution to the riddle of the giant panda's phylogeny.Nature. 1985 Sep 12-18;317(6033):140-4 PMID: 4033795
-
pEMBL: a new family of single stranded plasmids.Nucleic Acids Res. 1983 Mar 25;11(6):1645-55 PMID: 6300771
-
Variability within the rabbit C repeats and sequences shared with other SINES.Nucleic Acids Res. 1985 Feb 25;13(4):1073-88 PMID: 4000935
-
Rapid duplication and loss of genes coding for the alpha chains of hemoglobin.Proc Natl Acad Sci U S A. 1980 Apr;77(4):2158-62 PMID: 6929543
-
Sequences of human repetitive DNA, non-alpha-globin genes, and major histocompatibility locus genes.Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:1079-86 PMID: 6574860
-
Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.Proc Natl Acad Sci U S A. 1983 Jul;80(13):3963-5 PMID: 6575390
-
Evolution of the primate beta-globin gene region. High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee.J Mol Biol. 1985 Mar 5;182(1):21-9 PMID: 3999143
-
A monkey Alu sequence is flanked by 13-base pair direct repeats by an interrupted alpha-satellite DNA sequence.Proc Natl Acad Sci U S A. 1982 Mar;79(5):1497-500 PMID: 6280186
-
Nucleotide sequence of the delta-beta-globin intergenic segment in the macaque: structure and evolutionary rates in higher primates.J Mol Evol. 1987;24(4):297-308 PMID: 3110423
-
Evolution of Alu family repeats since the divergence of human and chimpanzee.J Mol Evol. 1985;22(4):316-22 PMID: 3003370
-
Insertion and/or deletion of many repeated DNA sequences in human and higher ape evolution.Proc Natl Acad Sci U S A. 1986 Jun;83(11):3875-9 PMID: 3012536
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
