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PMID: 2825116 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Messenger RNAs from the E1 region of bovine papillomavirus type 1 detected in virus-infected bovine cells.

Nucleic acids research ·Vol. 15 ·No. 21 ·1987-11-11 ·Pages 8607-20

Burnett S, Moreno-Lopez J, Pettersson U

Abstract

Bovine papillomavirus type 1 DNA replicated to a high copy number in virus-infected bovine fibroblasts. Infected bovine cells were therefore used as a source of RNA for Northern blotting analysis to search for viral transcripts hybridizing to the E1 gene region, implicated in viral DNA replication. Cytoplasmic polyadenylated RNA preparations contained at least five different E1-region transcripts, ranging from 1200 to approximately 4500 nucleotides in length. All of these species contained sequence information from the 5'-end of the E1 open reading frame, but only the largest species included sequences from its central portion. The latter transcript is a candidate mRNA for a stimulatory replication factor (R) previously mapped by genetic experiments (1).

MeSH Terms
Animals Bovine papillomavirus 1/genetics Cattle Cells, Cultured DNA, Viral/genetics Fibroblasts/metabolism Genes, Viral Mice Papillomaviridae/genetics RNA, Messenger/analysis RNA, Viral/analysis Species Specificity Transcription, Genetic
Chemicals
DNA, Viral RNA, Messenger RNA, Viral
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Burnett S
Department of Medical Genetics, University of Uppsala, Sweden.
Moreno-Lopez J
Pettersson U
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/15.21.8607
Published
1987-11-11
Pages
8607-20
Language
English
Region
England
NLM ID
0411011
PMCID
PMC306394
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/15.21.8607 PMC Full Text View journal details
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