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PMID: 28305718 Published · ppublish English Journal Article

Proximal-distal pattern formation inDrosophila: graded requirement forDistal-less gene activity during limb development.

Roux's archives of developmental biology : the official organ of the EDBO ·Vol. 198 ·No. 3 ·1989-10-00 ·Pages 157-169

Cohen SM, Jürgens G

Abstract

The development of all of the adult limbs inDrosophila depends upon the activity of theDistal-less gene. We report here the phenotypic characterization of a number of hypomorphicDistal-less alleles which indicates that there is a graded requirement forDistal-less activity in the developing limbs. Previous analysis of genetically mosaic animals indicated that cells in the early primordia of the limb imaginal dises possess a graded proximal-distal positional information which depends on the presence of theDistal-less gene for its expression. Taken together these data suggest thatDistal-less may directly encode the graded positional information that is required to organise the proximal-distal axis of the developing limbs.

Keywords
Distal less Drosophila Limb development
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cohen Stephen M
Institut für Genetik und Mikrobiologie, Universität München, Maria-Ward-St. 1 A, D-8000, München 19, Federal Republic of Germany.
Jürgens Gerd
Institut für Genetik und Mikrobiologie, Universität München, Maria-Ward-St. 1 A, D-8000, München 19, Federal Republic of Germany.
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Article Info
Journal
Roux's archives of developmental biology : the official organ of the EDBO
Abbr.
Rouxs Arch Dev Biol
ISSN
0930-035X
DOI
10.1007/BF02438941
Published
1989-10-00
Pages
157-169
Language
English
Region
Germany
NLM ID
8606607
External Links
PubMed source DOI: 10.1007/BF02438941
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