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PMID: 2837730 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Chromosome size polymorphism in Plasmodium falciparum can involve deletions of the subtelomeric pPFrep20 sequence.

Nucleic acids research ·Vol. 16 ·No. 10 ·1988-05-25 ·Pages 4331-40

Patarapotikul J, Langsley G

Abstract

The P. falciparum pPFrep20 repetitive element from the Palo Alto Uganda strain has been isolated and sequenced. The Palo Alto pPFrep20 repeat (pPFPArep20) has a clustered subtelomeric location and on chromosome 1 has been deleted from one end. Analysis of chromosome 1 from 5 other strains has revealed that pPFrep20 sequences have been deleted from one end in 3 of them. Thus, deletion of pPFrep20 appears to be a frequent event that could significantly contribute to chromosome size polymorphism in P. falciparum.

MeSH Terms
Animals Base Sequence Chromosome Deletion Chromosomes/ultrastructure DNA/genetics,isolation & purification DNA Restriction Enzymes Molecular Sequence Data Plasmodium falciparum/genetics Polymorphism, Genetic Repetitive Sequences, Nucleic Acid
Chemicals
DNA DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Patarapotikul J
Unit of Experimental Parasitology, Institut Pasteur, Paris, France.
Langsley G
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/16.10.4331
Published
1988-05-25
Pages
4331-40
Language
English
Region
England
NLM ID
0411011
PMCID
PMC336633
Subset
IM
External Links
PubMed source DOI: 10.1093/nar/16.10.4331 PMC Full Text View journal details
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