Home LiteratureArticle Details
PMID: 2841109 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Progressive loss of DNA sequences from terminal chromosome deficiencies in Drosophila melanogaster.

The EMBO journal ·Vol. 7 ·No. 4 ·1988-04-00 ·Pages 1081-6

Biessmann H, Mason JM

Abstract

Terminal deficiencies at the tip of the X chromosome can be induced at a high frequency (0.2-0.3%) by irradiating Drosophila females carrying a homozygous mutator (mu-2) with low doses of X-rays. These terminal deficiencies are unstable, since over a period of 3 1/2 years DNA sequences were lost from their distal ends at a rate of 75 bp per generation, presumably due to the absence of a complete wild-type telomeric structure. Breakpoints of these deletions in the 5' upstream regulatory region of the yellow gene, giving rise to a mosaic cuticle pigmentation pattern typical of the y2 type, were used to define the location of tissue-specific cis-acting regulatory elements that are required for body, wing or bristle pigmentation.

MeSH Terms
Animals Chromosomes/physiology Crosses, Genetic DNA/genetics,radiation effects DNA Restriction Enzymes Drosophila melanogaster/genetics Female Genes, Regulator Male Mutation X-Rays
Chemicals
DNA DNA Restriction Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Biessmann H
Developmental Biology Center, University of California, Irvine 92717.
Mason J M
References (41)
41 references, click to expand
  1. Genetic control of chromosome breakage and rejoining in Drosophila melanogaster: spontaneous chromosome aberrations in X-linked mutants defective in DNA metabolism.
    Proc Natl Acad Sci U S A. 1979 Mar;76(3):1377-81 PMID: 108678
  2. A DNA sequence of Drosophila melanogaster with a differential telomeric distribution.
    Chromosoma. 1984;89(3):206-11 PMID: 6425021
  3. DNA sequences of telomeres maintained in yeast.
    Nature. 1984 Jul 12-18;310(5973):154-7 PMID: 6330571
  4. Cloning of DNA sequences from the white locus of D. melanogaster by a novel and general method.
    Cell. 1981 Sep;25(3):693-704 PMID: 6269753
  5. The Stability of Broken Ends of Chromosomes in Zea Mays.
    Genetics. 1941 Mar;26(2):234-82 PMID: 17247004
  6. Identification of yeast mutants with altered telomere structure.
    Proc Natl Acad Sci U S A. 1986 Mar;83(5):1398-402 PMID: 3513174
  7. In support of the telomere concept.
    Genetics. 1975 May;80(1):135-42 PMID: 805753
  8. Genetic and physical studies of a portion of the white locus participating in transcriptional regulation and in synapsis-dependent interactions in Drosophila adult tissues.
    Genetics. 1985 Jul;110(3):479-94 PMID: 2991082
  9. CDC17: an essential gene that prevents telomere elongation in yeast.
    Cell. 1985 Aug;42(1):249-57 PMID: 3893744
  10. The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion.
    Proc Natl Acad Sci U S A. 1942 Nov;28(11):458-63 PMID: 16578057
  11. Interactions among the gypsy transposable element and the yellow and the suppressor of hairy-wing loci in Drosophila melanogaster.
    Mol Cell Biol. 1986 Jan;6(1):47-53 PMID: 3023836
  12. Chromosomal structure and arrangement of repeated DNA sequences in the telomeric heterochromatin of Secale cereale and its relatives.
    Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:1209-13 PMID: 6345071
  13. The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis.
    Proc Natl Acad Sci U S A. 1939 Aug;25(8):405-16 PMID: 16577924
  14. Discontinuous DNA replication of Drosophila melanogaster is primed by octaribonucleotide primer.
    Mol Cell Biol. 1984 Aug;4(8):1591-6 PMID: 6436687
  15. Forked, gypsys, and suppressors in Drosophila.
    Cell. 1985 Jun;41(2):429-37 PMID: 2985277
  16. Molecular analysis of the yellow gene (y) region of Drosophila melanogaster.
    Proc Natl Acad Sci U S A. 1985 Nov;82(21):7369-73 PMID: 3933004
  17. Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA.
    Cell. 1986 Oct 24;47(2):195-205 PMID: 3094961
  18. Long tandem arrays of complex repeat units in Chironomus telomeres.
    EMBO J. 1985 Mar;4(3):799-804 PMID: 4006906
  19. Telomere regions in Drosophila share complex DNA sequences with pericentric heterochromatin.
    Cell. 1983 Aug;34(1):85-94 PMID: 6411353
  20. Healing of broken linear dicentric chromosomes in yeast.
    Genetics. 1984 Feb;106(2):207-26 PMID: 6365688
  21. Growth of chromosome ends in multiplying trypanosomes.
    Nature. 1983 Jun 16-22;303(5918):592-7 PMID: 6304531
  22. Differential size variations between transcriptionally active and inactive telomeres of Trypanosoma brucei.
    Nucleic Acids Res. 1983 Dec 10;11(23):8137-47 PMID: 6324074
  23. Genetic regulation and pattern formation: a study of the yellow locus in Drosophila melanogaster.
    Genet Res. 1974 Aug;24(1):19-26 PMID: 4215694
  24. Control elements of the Drosophila segmentation gene fushi tarazu.
    Cell. 1985 Dec;43(3 Pt 2):603-13 PMID: 3935327
  25. Structure of the growing telomeres of Trypanosomes.
    Cell. 1984 Feb;36(2):459-68 PMID: 6319026
  26. Meiotic and mitotic behavior of dicentric chromosomes in Saccharomyces cerevisiae.
    Genetics. 1984 Feb;106(2):185-205 PMID: 6321297
  27. Dynamics of telomere length variation in Tetrahymena thermophila.
    Cell. 1987 Jul 31;50(3):477-83 PMID: 3607876
  28. A molecular description of telometic heterochromatin in secale species.
    Cell. 1980 Feb;19(2):545-60 PMID: 6244112
  29. Patterns of pigmentation color states regulated by the y locus in Drosophila melanogaster.
    Dev Biol. 1976 Feb;48(2):336-43 PMID: 815112
  30. Identification of a telomere-binding activity from yeast.
    Proc Natl Acad Sci U S A. 1986 Jun;83(11):3713-7 PMID: 3520552
  31. On the molecular mechanism of gypsy-induced mutations at the yellow locus of Drosophila melanogaster.
    EMBO J. 1986 Oct;5(10):2657-62 PMID: 3096713
  32. Telomeres: do the ends justify the means?
    Cell. 1984 May;37(1):7-8 PMID: 6722877
  33. Isolation of a telomeric DNA sequence from Drosophila melanogaster.
    Cold Spring Harb Symp Quant Biol. 1978;42 Pt 2:1041-6 PMID: 98261
  34. Separable cis-acting control elements for expression of the white gene of Drosophila.
    EMBO J. 1985 Dec 16;4(13A):3489-99 PMID: 3004962
  35. The molecular structure of centromeres and telomeres.
    Annu Rev Biochem. 1984;53:163-94 PMID: 6383193
  36. mu-2: mutator gene in Drosophila that potentiates the induction of terminal deficiencies.
    Proc Natl Acad Sci U S A. 1984 Oct;81(19):6090-4 PMID: 6435123
  37. Multiple upstream regulatory elements control the expression of the Drosophila white gene.
    EMBO J. 1985 Dec 16;4(13A):3501-8 PMID: 3004963
  38. Organization of DNA sequences and replication origins at yeast telomeres.
    Cell. 1983 Jun;33(2):563-73 PMID: 6345000
  39. Unusual DNA sequences associated with the ends of yeast chromosomes.
    Nature. 1984 Jul 12-18;310(5973):157-60 PMID: 6377091
  40. Molecular analysis of the yellow locus of Drosophila.
    EMBO J. 1986 Dec 20;5(13):3597-605 PMID: 16052739
  41. Independent control elements that determine yolk protein gene expression in alternative Drosophila tissues.
    Proc Natl Acad Sci U S A. 1985 Mar;82(5):1396-400 PMID: 3919395
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1988-04-00
Pages
1081-6
Language
English
Region
England
NLM ID
8208664
PMCID
PMC454439
Subset
IM
Grants
NIGMS NIH HHS · GM 32154 · United States
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2