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PMID: 2846286 Published · ppublish English Journal Article

Scanning independent ribosomal initiation of the Sendai virus X protein.

The EMBO journal ·Vol. 7 ·No. 9 ·1988-09-00 ·Pages 2869-74

Curran J, Kolakofsky D

Abstract

Both peptide antisera and monoclonal antibodies detect a 10-kd protein (X) in Sendai virus infected cells, which represents approximately the last 95 residues of the 568-amino-acid-long P protein. The X protein does not appear to be derived from a precursor P in vivo, and in in vitro X can be made under conditions in which P synthesis has been arrested by hybridized DNA fragments or specific cleavage of the mRNA. X initiation is nevertheless cap dependent. Ribosomes which initiate X appear to pass directly from the cap to the initiation codon.

MeSH Terms
Animals Cell Line Immunoblotting Parainfluenza Virus 1, Human/genetics,metabolism Phosphoproteins/biosynthesis,genetics Precipitin Tests Protein Biosynthesis RNA, Messenger/genetics,metabolism Ribosomes/metabolism Viral Proteins/biosynthesis,genetics
Chemicals
P protein, Sendai virus Phosphoproteins RNA, Messenger Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Curran J
Department of Microbiology, University of Geneva Medical School, Switzerland.
Kolakofsky D
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1988-09-00
Pages
2869-74
Language
English
Region
England
NLM ID
8208664
PMCID
PMC457080
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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