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PMID: 2847645 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Tn4201, a beta-lactamase transposon in Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 32 ·No. 8 ·1988-08-00 ·Pages 1164-9

Weber DA, Goering RV

Abstract

We report the preliminary characterization of a 6.7-kilobase transposon, Tn4201, encoding resistance to penicillin associated with the conjugative plasmid pCRG1600 in Staphylococcus aureus. Tn4201 is capable of inverting in orientation (frequently observed in derivatives of pCRG1600) and is expressed equally well in either orientation. The element is also capable of movement to alternative plasmid and chromosomal sites. Tn4201 exhibits rec-independent transposition in an apparent site-specific manner and may play an important role in the resistance of staphylococci to beta-lactam compounds.

MeSH Terms
Anti-Bacterial Agents/pharmacology Chromosome Inversion Chromosome Mapping Cloning, Molecular DNA Restriction Enzymes DNA Transposable Elements DNA, Bacterial/analysis Drug Resistance, Microbial Electrophoresis, Agar Gel Nucleic Acid Hybridization Penicillin Resistance/genetics R Factors Staphylococcus aureus/drug effects,enzymology,genetics Transduction, Genetic beta-Lactamases/genetics beta-Lactams
Chemicals
Anti-Bacterial Agents DNA Transposable Elements DNA, Bacterial beta-Lactams DNA Restriction Enzymes beta-Lactamases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Weber D A
Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178.
Goering R V
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.32.8.1164
Published
1988-08-00
Pages
1164-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172370
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.32.8.1164 PMC Full Text View journal details
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