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PMID: 2849763 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The structure of V alpha and J alpha segments in the mouse.

Nucleic acids research ·Vol. 16 ·No. 23 ·1988-12-09 ·Pages 11355-64

Yague J, Blackman M, Born W, Marrack P, Kappler J, Palmer E

Abstract

Antigen receptors on most T-cells are heterodimeric glycoproteins, comprised of an alpha chain and a beta chain. These chains are encoded by discontiguous variable (V), diversity (D) and joining (J) gene segments that rearrange to produce a contiguous and functional alpha or beta chain gene. To investigate the size and diversity of the germline repertoire of alpha-chain gene segments, we have characterized and sequenced 20 alpha chain cDNAs. Among these cDNA clones, we have found 4 J alpha and 4 V alpha sequences that have not yet been described. The relationship of these "new" gene segments to those already characterized is discussed.

MeSH Terms
Amino Acid Sequence Animals Antibody Diversity Base Sequence Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor Immunoglobulin Joining Region/genetics,isolation & purification Immunoglobulin Variable Region/genetics,isolation & purification Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular Sequence Data Multigene Family Receptors, Antigen, T-Cell/genetics Sequence Homology, Nucleic Acid
Chemicals
Immunoglobulin Joining Region Immunoglobulin Variable Region Receptors, Antigen, T-Cell
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Yague J
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO.
Blackman M
Born W
Marrack P
Kappler J
Palmer E
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/16.23.11355
Published
1988-12-09
Pages
11355-64
Language
English
Region
England
NLM ID
0411011
PMCID
PMC339015
Subset
IM
Grants
NIAID NIH HHS · AI22259 · United States
NIADDK NIH HHS · AM37070 · United States
External Links
PubMed source DOI: 10.1093/nar/16.23.11355 PMC Full Text View journal details
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