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PMID: 28808499 Published · ppublish English Journal Article Review

Epigenetics and Oxidative Stress in Aging.

Oxidative medicine and cellular longevity ·Vol. 2017 ·2017-00-00 ·Pages 9175806

Guillaumet-Adkins A, Yañez Y, Peris-Diaz MD, Calabria I, Palanca-Ballester C, Sandoval J

Abstract

Aging is a multifactorial process characterized by the progressive loss of physiological functions, leading to an increased vulnerability to age-associated diseases and finally to death. Several theories have been proposed to explain the nature of aging. One of the most known identifies the free radicals produced by the mitochondrial metabolism as the cause of cellular and DNA damage. However, there are also several evidences supporting that epigenetic modifications, such as DNA methylation, noncoding RNAs, and histone modifications, play a critical role in the molecular mechanism of aging. In this review, we explore the significance of these findings and argue how the interlinked effects of oxidative stress and epigenetics can explain the cause of age-related declines.

MeSH Terms
Aging Animals DNA Damage Epigenesis, Genetic Histones/metabolism Humans Mitochondria/metabolism Neurodegenerative Diseases/genetics,metabolism,pathology Oxidative Stress RNA, Untranslated/metabolism
Chemicals
Histones RNA, Untranslated
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Guillaumet-Adkins Amy
CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
Yañez Yania
Pediatric Oncology Unit, Hospital Universitari i Politècnic La Fe, Avda Fernando Abril Martorell, 46026 Valencia, Spain.
Peris-Diaz Manuel D
Biomarkers and Precision Medicine Unit, Health Research Institute La Fe, Avda Fernando Abril Martorell, 46026 Valencia, Spain.
Calabria Ines
Genomics Unit, Health Research Institute La Fe, Avda Fernando Abril Martorell, 46026 Valencia, Spain.
Palanca-Ballester Cora
Biomarkers and Precision Medicine Unit, Health Research Institute La Fe, Avda Fernando Abril Martorell, 46026 Valencia, Spain.
Sandoval Juan ORCID
Biomarkers and Precision Medicine Unit, Health Research Institute La Fe, Avda Fernando Abril Martorell, 46026 Valencia, Spain. | Epigenomics Core Facility, Health Research Institute La Fe, Avda Fernando Abril Martorell, 46026 Valencia, Spain.
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Article Info
Journal
Oxidative medicine and cellular longevity
Abbr.
Oxid Med Cell Longev
ISSN
1942-0994
DOI
10.1155/2017/9175806
Published
2017-00-00
Epub
2017-00-20
Pages
9175806
Language
English
Region
United States
NLM ID
101479826
PMCID
PMC5541801
Subset
IM
External Links
PubMed source DOI: 10.1155/2017/9175806 PMC Full Text
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