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PMID: 291992 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Studies on murine Ss protein: demonstration that S region encodes structural gene for fourth component of complement.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 76 ·No. 9 ·1979-09-00 ·Pages 4641-5

Carroll MC, Capra JD

Abstract

Although genes controlling the expression of certain complement components have been shown to be linked to the major histocompatibility complex of several species, the structural genes that encode these molecules have been more difficult to map. In this study, the three constitutive polypeptide chains of the fourth component of murine complement (C4) (alpha, beta, and gamma) were isolated from 14 different inbred strains and compared by peptide mapping on analytical sodium dodecyl sulfate gels. The peptide patterns of the alpha and gamma subunits appeared to be nearly identical, but two distinctly different patterns were observed for the C4 beta chain. This structural variant was mapped to the S or G region and, as such, provides direct evidence that a structural gene for a complement component is encoded within a major histocompatibility complex.

MeSH Terms
Animals Chromosome Mapping Complement C4/analysis,genetics Genes Macromolecular Substances Major Histocompatibility Complex Mice Peptide Fragments/analysis
Chemicals
Complement C4 Macromolecular Substances Peptide Fragments
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Carroll M C
Capra J D
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35 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.76.9.4641
Published
1979-09-00
Pages
4641-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC411635
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.76.9.4641 PMC Full Text View journal details
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