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PMID: 2921031 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Regional localization of the TIMP gene on the human X chromosome. Extension of a conserved synteny and linkage group on proximal Xp.

Human genetics ·Vol. 81 ·No. 3 ·1989-02-00 ·Pages 234-8

Willard HF, Durfy SJ, Mahtani MM, Dorkins H, Davies KE, Williams BR

Abstract

The gene encoding a tissue inhibitor of metallo-proteinases, TIMP, has previously been shown to be X-linked in both the human and mouse genomes. We have used a series of somatic cell hybrids segregating translocation and deletion X chromosomes to map the TIMP gene on the human X chromosome. In combination with previous data, the gene can be assigned to Xp11.23----Xp11.4. Genetic linkage analyses demonstrate that TIMP is linked to the more distal ornithine transcarbamylase (OTC) locus at a distance of about 22 centimorgans. The data are consistent with the conclusion that TIMP maps to a conserved synteny and linkage group on the proximal short arm of the human X chromosome and on the pericentric region of the mouse X chromosome, including loci for synapsin-1, a member of the raf oncogene family, OTC, and TIMP.

MeSH Terms
Animals Blotting, Southern Chromosome Mapping Cricetinae DNA Probes Enzyme Inhibitors/genetics Genetic Linkage Humans Hybrid Cells Metalloendopeptidases/antagonists & inhibitors Tissue Inhibitor of Metalloproteinases X Chromosome
Chemicals
DNA Probes Enzyme Inhibitors Tissue Inhibitor of Metalloproteinases Metalloendopeptidases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Willard H F
Department of Medical Genetics, University of Toronto, Ontario, Canada.
Durfy S J
Mahtani M M
Dorkins H
Davies K E
Williams B R
References (36)
36 references, click to expand
  1. X-linked genetic homologies between mouse and man.
    Genomics. 1987 Nov;1(3):213-27 PMID: 3328737
  2. Report of the committee on the genetic constitution of the X and Y chromosomes.
    Cytogenet Cell Genet. 1987;46(1-4):277-315 PMID: 3507278
  3. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.
    EMBO J. 1987 Jul;6(7):1899-904 PMID: 2820711
  4. Human X chromosome markers and Duchenne muscular dystrophy.
    Nucleic Acids Res. 1985 May 24;13(10):3419-26 PMID: 3859837
  5. Lysyl oxidase deficiency in Ehlers-Danlos syndrome type V.
    Connect Tissue Res. 1975;3(1):49-53 PMID: 240645
  6. Human beta-hexosaminidase alpha chain: coding sequence and homology with the beta chain.
    Proc Natl Acad Sci U S A. 1985 Dec;82(23):7830-4 PMID: 2933746
  7. Duchenne muscular dystrophy involving translocation of the dmd gene next to ribosomal RNA genes.
    Science. 1984 Jun 29;224(4656):1447-9 PMID: 6729462
  8. The genetic linkage map of the human X chromosome.
    Science. 1985 Nov 15;230(4727):753-8 PMID: 4059909
  9. Regional mapping panel for human chromosome 17: application to neurofibromatosis type 1.
    Genomics. 1987 Dec;1(4):374-81 PMID: 3130306
  10. A primary genetic map of the pericentromeric region of the human X chromosome.
    Genomics. 1988 May;2(4):294-301 PMID: 2906040
  11. Alterations in copper and collagen metabolism in the Menkes syndrome and a new subtype of the Ehlers-Danlos syndrome.
    Biochemistry. 1983 Dec 20;22(26):6156-63 PMID: 6140952
  12. Genes for synapsin I, a neuronal phosphoprotein, map to conserved regions of human and murine X chromosomes.
    Proc Natl Acad Sci U S A. 1986 Nov;83(22):8679-83 PMID: 3095840
  13. Multilocus molecular mapping of the mouse X chromosome.
    Genomics. 1988 Oct;3(3):187-94 PMID: 2906327
  14. Segregation analysis of a marker localised Xp21.2-Xp21.3 in Duchenne and Becker muscular dystrophy families.
    Hum Genet. 1985;71(2):103-7 PMID: 2995231
  15. Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.
    Proc Natl Acad Sci U S A. 1986 Jun;83(11):3934-8 PMID: 3520560
  16. Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse.
    Genomics. 1988 Apr;2(3):220-30 PMID: 2899541
  17. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity.
    Nature. 1985 Nov 7-13;318(6041):66-9 PMID: 3903517
  18. Menkes syndrome in a girl with X-autosome translocation.
    Am J Med Genet. 1987 Feb;26(2):503-10 PMID: 3812600
  19. A sex-linked defect in the cross-linking of collagen and elastin associated with the mottled locus in mice.
    J Exp Med. 1974 Jan 1;139(1):180-92 PMID: 4808708
  20. MspI RFLP detected with chromosome-walk clone pXUT23-SE3.2L from DXS16 in Xp22.1-22.3.
    Nucleic Acids Res. 1987 Nov 25;15(22):9614 PMID: 2446265
  21. Human ornithine transcarbamylase locus mapped to band Xp21.1 near the Duchenne muscular dystrophy locus.
    Science. 1984 Nov 9;226(4675):698-700 PMID: 6494904
  22. Comparative gene mapping: order of loci on the X chromosome is different in mice and humans.
    Proc Natl Acad Sci U S A. 1980 Jun;77(6):3595-9 PMID: 6251472
  23. Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders.
    Science. 1985 Nov 22;230(4728):940-2 PMID: 3840606
  24. Report of the Committee on the Genetic Constitution of the X and Y Chromosomes.
    Cytogenet Cell Genet. 1985;40(1-4):296-352 PMID: 3864598
  25. Linkage studies in Menkes' disease. The Xg blood group system and C-banding of the X chromosome.
    Ann Hum Genet. 1984 May;48(Pt 2):161-72 PMID: 6742777
  26. Chromosomal assignment of the gene encoding the human tissue inhibitor of metalloproteinases to Xp11.1-p11.4.
    Ann Hum Genet. 1987 Jul;51(Pt 3):189-94 PMID: 3688834
  27. RFLP detected by an X-linked cDNA encoding erythroid-potentiating activity/tissue inhibitor of metalloproteinase (EPA/TIMP).
    Nucleic Acids Res. 1986 Nov 25;14(22):9226 PMID: 2878423
  28. The William Allan memorial award address: X-chromosome inactivation and the location and expression of X-linked genes.
    Am J Hum Genet. 1988 Jan;42(1):8-16 PMID: 3276178
  29. Localization of DNA sequences in region Xp21 of the human X chromosome: search for molecular markers close to the Duchenne muscular dystrophy locus.
    Am J Hum Genet. 1985 Mar;37(2):235-49 PMID: 2984924
  30. X-linked cutis laxa: defective cross-link formation in collagen due to decreased lysyl oxidase activity.
    N Engl J Med. 1980 Jul 10;303(2):61-5 PMID: 6104292
  31. Mapping DNA sequences in a human X-chromosome deletion which extends across the region of the Duchenne muscular dystrophy mutation.
    Am J Hum Genet. 1985 May;37(3):451-62 PMID: 2988331
  32. Localization of the gene encoding human erythroid-potentiating activity to chromosome region Xp11.1----Xp11.4.
    Am J Hum Genet. 1986 Jun;38(6):819-26 PMID: 3460333
  33. Assignment of the TIMP gene to the murine X-chromosome using an inter-species cross.
    Nucleic Acids Res. 1987 May 26;15(10):4357 PMID: 3588297
  34. Evidence that the Menkes locus maps on proximal Xp.
    Hum Genet. 1983;65(1):72-3 PMID: 6580259
  35. Molecular characterization and expression of the gene encoding human erythroid-potentiating activity.
    Nature. 1985 Jun 27-Jul 3;315(6022):768-71 PMID: 3839290
  36. Genomic organization of alpha satellite DNA on human chromosome 7: evidence for two distinct alphoid domains on a single chromosome.
    Mol Cell Biol. 1987 Jan;7(1):349-56 PMID: 3561394
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00278995
Published
1989-02-00
Pages
234-8
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00278995 View journal details
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