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PMID: 2963697 Published · ppublish English Journal Article

Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice.

Cell and tissue research ·Vol. 251 ·No. 1 ·1988-01-00 ·Pages 87-93

Satoh Y

Abstract

Germ-free mice were given live or heat-killed facultative anaerobes, and the ultrastructure of ileal Paneth cells was quantitatively examined with special reference to secretory granules showing a bipartite substructure (central core and peripheral halo). After administering live or heat-killed bacteria, there was a decrease in the area occupied by the cores of secretory granules in Paneth cells, and exocytosed core material was observed in the crypt lumen. There were no changes in the area occupied by the halo of secretory granules. None of the examined Paneth cells phagocytosed bacteria. It is concluded that certain bacteria may affect the secretion of antibacterial agents contained in the secretory granules of Paneth cells.

MeSH Terms
Animals Bacillus Cytoplasmic Granules/ultrastructure Enterococcus faecalis Escherichia coli Exocytosis Germ-Free Life Ileum/cytology,microbiology Intestinal Mucosa/cytology,microbiology,physiology Male Mice Mice, Inbred Strains Microscopy, Electron Species Specificity Specific Pathogen-Free Organisms
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Satoh Y
Department of Anatomy, Asahikawa Medical College, Japan.
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Article Info
Journal
Cell and tissue research
Abbr.
Cell Tissue Res
ISSN
0302-766X
DOI
10.1007/BF00215451
Published
1988-01-00
Pages
87-93
Language
English
Region
Germany
NLM ID
0417625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00215451 View journal details
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