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PMID: 2971756 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.

The Journal of experimental medicine ·Vol. 168 ·No. 4 ·1988-10-01 ·Pages 1247-53

Letarte M, Vera S, Tran R, Addis JB, Onizuka RJ, Quackenbush EJ, Jongeneel CV, McInnes RR

Abstract

We purified CALLA from human kidney and isolated a cDNA clone reactive with two oligonucleotide probes corresponding to two distinct peptides. The amino acid sequence translated from the CALLA cDNA revealed 100% identity with that of human neutral endopeptidase (NEP, enkephalinase). The distribution of CALLA antigen and NEP in normal tissues are similar.

MeSH Terms
Amino Acid Sequence Antigens, Differentiation/genetics Antigens, Neoplasm/genetics Antigens, Surface/genetics,immunology Base Sequence Blotting, Northern Chromatography, Affinity Cloning, Molecular DNA Probes DNA, Neoplasm/genetics Humans Kidney Cortex/enzymology,immunology Molecular Sequence Data Neprilysin/genetics,immunology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis,immunology RNA, Neoplasm/genetics
Chemicals
Antigens, Differentiation Antigens, Neoplasm Antigens, Surface DNA Probes DNA, Neoplasm RNA, Neoplasm Neprilysin
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Letarte M
Department of Immunology, Hospital for Sick Children, Toronto, Canada.
Vera S
Tran R
Addis J B
Onizuka R J
Quackenbush E J
Jongeneel C V
McInnes R R
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31 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.168.4.1247
Published
1988-10-01
Pages
1247-53
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189092
Subset
IM
Databases
GENBANK
Y00811
External Links
PubMed source DOI: 10.1084/jem.168.4.1247 PMC Full Text View journal details
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