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PMID: 2985974 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic mapping of a cellular DNA region involved in induction of thymic lymphomas (Mlvi-1) to mouse chromosome 15.

Molecular and cellular biology ·Vol. 5 ·No. 4 ·1985-04-00 ·Pages 894-7

Kozak CA, Strauss PG, Tsichlis PN

Abstract

Mlvi-1 defines a genetic locus representing a common domain for proviral DNA integration in Moloney murine leukemia virus-induced rat thymic lymphomas. Cellular sequences homologous to Mlvi-1 are present in mouse DNA, and we have used hamster-mouse somatic cell hybrids to chromosomally map Mlvi-1 in the mouse genome. Results demonstrated that Mlvi-1 maps to mouse chromosome 15 and that it is distinct from the Mlvi-2 integration region and from the cellular oncogenes c-myc and c-sis, which also map to this chromosome. Therefore, Mlvi-1 may contain novel sequences involved in the establishment and maintenance of virus-induced murine tumors, many of which contain abnormalities of chromosome 15.

MeSH Terms
Animals Base Sequence Cell Transformation, Viral Chromosome Mapping DNA Restriction Enzymes DNA, Neoplasm/genetics Lymphoma/genetics Mice Moloney murine leukemia virus/genetics Oncogenes Recombination, Genetic Thymus Gland
Chemicals
DNA, Neoplasm DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kozak C A
Strauss P G
Tsichlis P N
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37 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.5.4.894-897.1985
Published
1985-04-00
Pages
894-7
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC366796
Subset
IM
Grants
NCI NIH HHS · 1R01CA38047-01 · United States
External Links
PubMed source DOI: 10.1128/mcb.5.4.894-897.1985 PMC Full Text View journal details
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