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PMID: 6321961 Published · ppublish English Journal Article

Mouse mammary tumor virus integration regions int-1 and int-2 map on different mouse chromosomes.

Molecular and cellular biology ·Vol. 4 ·No. 2 ·1984-02-00 ·Pages 375-8

Peters G, Kozak C, Dickson C

Abstract

Two regions of mouse DNA which constitute common provirus integration sites in tumors induced by mouse mammary tumor virus have been identified and designated int-1 and int-2. By examining a series of hamster-mouse somatic cell hybrids, we mapped the int-2 locus to mouse chromosome 7 and confirmed the previous assignment of int-1 to chromosome 15. This constitutes proof that int-1 and int-2 are discrete genetic loci. It is therefore possible that proviral activation of two distinct cellular genes may result in the same neoplastic disease.

MeSH Terms
Animals Chromosome Mapping DNA/analysis Hybrid Cells Mammary Tumor Virus, Mouse/genetics Mice Oncogenes
Chemicals
DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Peters G
Kozak C
Dickson C
References (21)
21 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.4.2.375-378.1984
Published
1984-02-00
Pages
375-8
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC368706
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.4.2.375-378.1984 PMC Full Text View journal details
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