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PMID: 2987521 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cervical papillomaviruses segregate within morphologically distinct precancerous lesions.

Journal of virology ·Vol. 54 ·No. 3 ·1985-06-00 ·Pages 675-81

Crum CP, Mitao M, Levine RU, Silverstein S

Abstract

We combined molecular hybridization and histological analysis of 58 biopsy samples from the uterine cervix to correlate the presence of certain strains of human papillomaviruses (HPVs) with specific pathological changes. HPV sequences were frequently detected (85%) in biopsies that contained a broad spectrum of precancerous changes. The presence of HPV 16 correlated strongly with precancers that exhibited morphological aberrations commonly found in invasive carcinomas and precancers that have a high risk of progression. This association underscores the potential importance of HPV type 16 in the genesis of genital cancers and emphasizes the value of histological analysis for detecting potentially oncogenic HPVs.

MeSH Terms
Base Sequence DNA, Viral/analysis Female Humans Papillomaviridae/classification,genetics Precancerous Conditions/microbiology,pathology Uterine Cervical Neoplasms/microbiology,pathology
Chemicals
DNA, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Crum C P
Mitao M
Levine R U
Silverstein S
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18 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.54.3.675-681.1985
Published
1985-06-00
Pages
675-81
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254851
Subset
IM
Grants
NCI NIH HHS · CA 13696 · United States
NCI NIH HHS · CA 23767 · United States
External Links
PubMed source DOI: 10.1128/JVI.54.3.675-681.1985 PMC Full Text View journal details
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