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PMID: 2995445 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Deoxyribonucleic acid polymorphism in the apolipoprotein A-1-C-III gene cluster. Association with hypertriglyceridemia.

The Journal of clinical investigation ·Vol. 76 ·No. 3 ·1985-09-00 ·Pages 1090-5

Rees A, Stocks J, Sharpe CR, Vella MA, Shoulders CC, Katz J, Jowett NI, Baralle FE, Galton DJ

Abstract

A DNA sequence polymorphism, revealed by digestion of human DNA with the restriction endonuclease Sst-1 and hybridization with an apolipoprotein A-I complementary DNA clone, has been shown to be located in or close to the 3' noncoding region of the apolipoprotein C-III gene. This polymorphism is found in significantly increased prevalence (P less than 0.001) in Caucasian hypertriglyceridemic subjects compared with race-matched controls, and its distribution in normal individuals of differing racial origins is reported. Furthermore, no alteration of high density lipoprotein or apolipoprotein A-I and apolipoprotein C-III phenotypes was observed in individuals with or without the polymorphism.

MeSH Terms
Adolescent Apolipoprotein A-I Apolipoprotein C-III Apolipoproteins A/blood,genetics Apolipoproteins C/blood,genetics Child China/ethnology DNA/genetics DNA Restriction Enzymes/metabolism Deoxyribonucleases, Type II Site-Specific Female Genes Genotype Humans Hyperlipoproteinemia Type IV/genetics Isoelectric Focusing Lipoproteins, HDL/blood Male Pedigree Polymorphism, Genetic Whites
Chemicals
Apolipoprotein A-I Apolipoprotein C-III Apolipoproteins A Apolipoproteins C Lipoproteins, HDL DNA DNA Restriction Enzymes endodeoxyribonuclease SacI Deoxyribonucleases, Type II Site-Specific
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Rees A
Stocks J
Sharpe C R
Vella M A
Shoulders C C
Katz J
Jowett N I
Baralle F E
Galton D J
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18 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI112062
Published
1985-09-00
Pages
1090-5
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC423995
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI112062 PMC Full Text View journal details
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