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PMID: 2996497 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mast-cell products and heparin stimulate the production of mononuclear-cell factor by cultured human monocyte/macrophages.

The Biochemical journal ·Vol. 230 ·No. 1 ·1985-08-15 ·Pages 83-8

Yoffe JR, Taylor DJ, Woolley DE

Abstract

Purified mast cells derived from rat peritoneal fluids and dog mastocytomas were extracted with 1 M-NaCl and sonication techniques. The mast-cell products increased the production of mononuclear cell factor from human peripheral blood mononuclear cells in culture, as judged by the enhanced stimulation of prostaglandin E (2-5 fold) and collagenase (3-11-fold) production by cultured adherent synovial cells. Heparin alone (1-10 micrograms/ml) induced a similar stimulation of mononuclear-cell-factor production by monocyte cultures, whereas histamine (1-10 micrograms/ml) had no effect. The stimulatory effect of mast-cell products and heparin represented a direct effect on mononuclear cells; they did not potentiate the effect of monokine on the synovial cells. These results suggest that mast-cell-macrophage interactions may play a significant role in the pathogenesis of inflammation and connective-tissue degradation.

MeSH Terms
Cells, Cultured Heparin/pharmacology Histamine/pharmacology Humans Leukocytes/drug effects,metabolism Macrophages/metabolism Mast Cells/metabolism Microbial Collagenase/metabolism Monokines Mononuclear Phagocyte System/metabolism Prostaglandins E/metabolism Protein Biosynthesis
Chemicals
Monokines Prostaglandins E Histamine Heparin Microbial Collagenase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yoffe J R
Taylor D J
Woolley D E
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33 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj2300083
Published
1985-08-15
Pages
83-8
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1152589
Subset
IM
External Links
PubMed source DOI: 10.1042/bj2300083 PMC Full Text View journal details
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