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PMID: 2996982 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cellular genes in the mouse regulate in trans the expression of endogenous mouse mammary tumor viruses.

Genetics ·Vol. 111 ·No. 3 ·1985-11-00 ·Pages 597-615

Traina-Dorge VL, Carr JK, Bailey-Wilson JE, Elston RC, Taylor BA, Cohen JC

Abstract

The transcriptional activities of the eleven mouse mammary tumor virus (MMTV) proviruses endogenous to two sets of recombinant inbred (RI) mouse strains, BXD and BXH, were characterized. Comparison of the levels of virus-specific RNA quantitated in each strain showed no direct relationship between the presence of a particular endogenous provirus or with increasing numbers of proviruses. Association of specific genetic markers with the level of MMTV-specific RNA was examined by using multiple regression analysis. Several cellular loci as well as proviral loci were identified that were significantly associated with viral expression. Importantly, these cellular loci associated with MMTV expression segregated independently of viral sequences.

MeSH Terms
Alleles Animals Cell Transformation, Neoplastic Female Genes, Viral Lipopolysaccharides/pharmacology Mammary Tumor Virus, Mouse/drug effects,genetics Mice Mice, Inbred Strains Nucleic Acid Hybridization Oncogenes RNA, Viral/genetics,isolation & purification Species Specificity Transcription, Genetic
Chemicals
Lipopolysaccharides RNA, Viral
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Traina-Dorge V L
Carr J K
Bailey-Wilson J E
Elston R C
Taylor B A
Cohen J C
References (12)
12 references, click to expand
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/111.3.597
Published
1985-11-00
Pages
597-615
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1202660
Subset
IM
Grants
NCI NIH HHS · R01-CA-28198 · United States
NCI NIH HHS · R01-CA-34823 · United States
NIGMS NIH HHS · R01-GM-18684 · United States
External Links
PubMed source DOI: 10.1093/genetics/111.3.597 PMC Full Text View journal details
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