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PMID: 299769 Published · ppublish English Journal Article

The adjuvant effect of Corynebacterium parvum: T-cell dependence of macrophage activation.

The Journal of experimental medicine ·Vol. 145 ·No. 1 ·1977-01-01 ·Pages 45-57

Sljivić VS, Watson SR

Abstract

Splenic and peritoneal macrophages from mice treated with Corynebacterium parvum enhanced the antibody response in vitro of normal nonadherent spleen cells to SRBC, but not to DNP-POL. This enhancement was dependent on the dose and time of administration of C. parvum and could be abrogated by pretreatment with carrageenan. Macrophages from T-cell-depleted mice failed to enhance the response, but this ability was restored if the mice had been reconstituted with purified T lymphocytes. Macrophages that are activated by C. parvum are a resident nondividing population. It is postulated that activated macrophages, capable of enhancing antibody responses to T-cell-dependent antigens, arise through a cell-mediated reaction to C. parvum.

MeSH Terms
Adjuvants, Immunologic Animals Antibody Formation/drug effects Antigens Ascitic Fluid/cytology Carrageenan/pharmacology Dinitrobenzenes/immunology Erythrocytes/immunology Female Hemocyanins/immunology Macrophages/immunology Mice Mice, Inbred CBA Propionibacterium acnes/immunology Spleen/immunology T-Lymphocytes/immunology Time Factors
Chemicals
Adjuvants, Immunologic Antigens Dinitrobenzenes Carrageenan Hemocyanins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sljivić V S
Watson S R
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54 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.145.1.45
Published
1977-01-01
Pages
45-57
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180586
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.145.1.45 PMC Full Text View journal details
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