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PMID: 2998290 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A seroepidemiological study of cytomegalovirus and Epstein-Barr virus in rheumatoid arthritis and sicca syndrome.

Annals of the rheumatic diseases ·Vol. 44 ·No. 11 ·1985-11-00 ·Pages 742-6

Venables PJ, Ross MG, Charles PJ, Melsom RD, Griffiths PD, Maini RN

Abstract

Antibodies to cytomegalovirus (CMV) and Epstein-Barr virus capsid antigen (EBVCA) were examined in 41 patients with rheumatoid arthritis (RA), 26 patients with primary sicca syndrome, and 26 healthy subjects of similar age and sex. IgG antibody titres to EBVCA and CMV were similar in all three groups, apart from a trivial increase of antibodies to EBVCA in RA. False positive IgM anti-CMV antibodies detected in serum from one patient with sicca syndrome and 20 patients with RA were shown to be due to rheumatoid factors. These data did not support recent suggestions that patients with these diseases showed exaggerated immunological responses to either virus and emphasised the need to incorporate adequate laboratory and disease controls when seroepidemiological studies are performed on sera containing rheumatoid factors and autoantibodies.

MeSH Terms
Adult Aged Antibodies, Viral/analysis Arthritis, Rheumatoid/etiology,immunology Cytomegalovirus/immunology Cytomegalovirus Infections/complications,diagnosis Female Herpesviridae Infections/complications,diagnosis Herpesvirus 4, Human/immunology Humans Immunoglobulin G/analysis Male Middle Aged Sjogren's Syndrome/etiology
Chemicals
Antibodies, Viral Immunoglobulin G
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Venables P J
Ross M G
Charles P J
Melsom R D
Griffiths P D
Maini R N
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Article Info
Journal
Annals of the rheumatic diseases
Abbr.
Ann Rheum Dis
ISSN
0003-4967
DOI
10.1136/ard.44.11.742
Published
1985-11-00
Pages
742-6
Language
English
Region
England
NLM ID
0372355
PMCID
PMC1001762
Subset
IM
External Links
PubMed source DOI: 10.1136/ard.44.11.742 PMC Full Text View journal details
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