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PMID: 2999289 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

The Journal of experimental medicine ·Vol. 162 ·No. 6 ·1985-12-01 ·Pages 2163-8

Dayer JM, Beutler B, Cerami A

Abstract

Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia and shock, has been found capable of stimulating collagenase and prostaglandin E2 (PGE2) production by isolated human synovial cells and dermal fibroblasts. This bioactivity associated with cachectin is comparable to that observed with the monokine interleukin 1 (IL-1), previously suggested as the major mediator of proteolysis. The ability of cachectin/TNF to stimulate collagenase and PGE2 production suggests that it may play a role in tissue destruction and remodelling, as these processes occur in inflammatory diseases.

MeSH Terms
Animals Dinoprostone Fibroblasts/enzymology,metabolism Glycoproteins/physiology Humans Interferon Type I/pharmacology Interleukin-1/physiology Mice Microbial Collagenase/biosynthesis Monokines Prostaglandins E/biosynthesis Proteins/physiology Recombinant Proteins Skin Synovial Membrane/cytology,enzymology,metabolism Tumor Necrosis Factor-alpha
Chemicals
Glycoproteins Interferon Type I Interleukin-1 Monokines Prostaglandins E Proteins Recombinant Proteins Tumor Necrosis Factor-alpha Microbial Collagenase Dinoprostone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dayer J M
Beutler B
Cerami A
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20 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.162.6.2163
Published
1985-12-01
Pages
2163-8
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2187983
Subset
IM
Grants
NIADDK NIH HHS · AM01314 · United States
External Links
PubMed source DOI: 10.1084/jem.162.6.2163 PMC Full Text View journal details
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