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PMID: 2999420 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Polyomavirus middle T protein encoded by a retrovirus transforms nonestablished chicken embryo cells.

Journal of virology ·Vol. 56 ·No. 3 ·1985-12-00 ·Pages 1023-6

Kaplan PL, Simon S, Eckhart W

Abstract

A murine retrovirus encoding the middle T protein of polyomavirus infected and transformed nonestablished chicken embryo cells. The infected cultures formed colonies in soft agar-containing medium and released infectious transforming virus. Middle T protein expressed in the transformed chicken cells associated with p60c-src and, in immunoprecipitates, enhanced the tyrosine protein kinase activity of p60c-src.

MeSH Terms
Animals Antigens, Viral, Tumor/genetics Cell Transformation, Viral Cells, Cultured Chick Embryo DNA, Recombinant Enzyme Activation Gene Expression Regulation Leukemia Virus, Murine/genetics Molecular Weight Oncogene Protein pp60(v-src) Phosphoproteins/metabolism Polyomavirus/genetics,immunology Protein-Tyrosine Kinases/metabolism Retroviridae Proteins/metabolism
Chemicals
Antigens, Viral, Tumor DNA, Recombinant Phosphoproteins Retroviridae Proteins Protein-Tyrosine Kinases Oncogene Protein pp60(v-src)
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kaplan P L
Simon S
Eckhart W
References (18)
18 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.56.3.1023-1026.1985
Published
1985-12-00
Pages
1023-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC252678
Subset
IM
Grants
NCI NIH HHS · CA-13884 · United States
NCI NIH HHS · CA-14195 · United States
External Links
PubMed source DOI: 10.1128/JVI.56.3.1023-1026.1985 PMC Full Text View journal details
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