Home LiteratureArticle Details
PMID: 3008075 Published · ppublish English Journal Article

Quinolones: pharmacology.

Pharmaceutisch weekblad. Scientific edition ·Vol. 8 ·No. 1 ·1986-02-21 ·Pages 22-5

Verbist L

Abstract

The quinolones are synthetic antibiotics chemically related to nalidixic acid. Since its introduction, several structural analogues have been synthesized. A fundamental breakthrough was the addition of a fluorine atom. The quinolones interfere with bacterial DNA transcription by inhibiting the enzyme DNA gyrase, that so far has only been found in bacteria. The nature of the activity of the quinolones on DNA gyrase makes it highly unlikely that resistance is carried on plasmids.

MeSH Terms
Anti-Bacterial Agents/pharmacology Bacteria/drug effects Chemical Phenomena Chemistry Drug Resistance, Microbial Nalidixic Acid/pharmacology Quinolines/pharmacology Topoisomerase II Inhibitors
Chemicals
Anti-Bacterial Agents Quinolines Topoisomerase II Inhibitors Nalidixic Acid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Verbist L
References (24)
24 references, click to expand
  1. Bioevaluation of the antibacterial flumequine for urinary tract use.
    Antimicrob Agents Chemother. 1976 Jul;10(1):20-4 PMID: 984753
  2. Mode of incomplete cross-resistance among pipemidic, piromidic, and nalidixic acids.
    Antimicrob Agents Chemother. 1978 Aug;14(2):240-5 PMID: 358918
  3. Piromidic acid, a new antibacterial agent: antibacterial properties.
    Antimicrob Agents Chemother (Bethesda). 1970;10:117-22 PMID: 4939730
  4. Compound 64716, a new synthetic antibacterial agent.
    Antimicrob Agents Chemother. 1973 Oct;4(4):415-20 PMID: 4791302
  5. Energy coupling in DNA gyrase and the mechanism of action of novobiocin.
    Proc Natl Acad Sci U S A. 1978 Oct;75(10):4838-42 PMID: 368801
  6. In vitro antibacterial activity of AM-715, a new nalidixic acid analog.
    Antimicrob Agents Chemother. 1980 Feb;17(2):103-8 PMID: 6446258
  7. Oxolinic acid, a new synthetic antimicrobial agent. I. In vivtro and in vivo activity.
    Antimicrob Agents Chemother (Bethesda). 1967;7:475-9 PMID: 5596176
  8. Mechanism of action of nalidixic acid: purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme.
    Proc Natl Acad Sci U S A. 1977 Nov;74(11):4767-71 PMID: 200930
  9. IN VITRO ANTIBACTERIAL PROPERTIES OF NALIDIXIC ACID, A NEW DRUG ACTIVE AGAINST GRAM-NEGATIVE ORGANISMS.
    Antimicrob Agents Chemother (Bethesda). 1963;161:583-7 PMID: 14274966
  10. DNA gyrase: an enzyme that introduces superhelical turns into DNA.
    Proc Natl Acad Sci U S A. 1976 Nov;73(11):3872-6 PMID: 186775
  11. 1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS.
    J Med Pharm Chem. 1962 Sep;91:1063-5 PMID: 14056431
  12. DNA topoisomerases.
    Annu Rev Biochem. 1981;50:879-910 PMID: 6267993
  13. Nalidixic Acid and the Metabolism of Escherichia coli.
    J Bacteriol. 1970 Dec;104(3):1168-75 PMID: 16559090
  14. Differential effects of antibiotics inhibiting gyrase.
    J Bacteriol. 1982 Jan;149(1):92-8 PMID: 6274849
  15. In vitro susceptibilities of 393 recent clinical isolates to WIN 49375, cefotaxime, tobramycin, and piperacillin.
    Antimicrob Agents Chemother. 1984 Mar;25(3):377-9 PMID: 6326666
  16. Superhelical Escherichia coli DNA: relaxation by coumermycin.
    J Mol Biol. 1978 Apr 5;120(2):145-54 PMID: 347091
  17. In vitro activity of Bay 09867, a new quinoline derivative, compared with those of other antimicrobial agents.
    Antimicrob Agents Chemother. 1983 Apr;23(4):559-64 PMID: 6222695
  18. In vitro activity of ciprofloxacin, norfloxacin and nalidixic acid.
    Eur J Clin Microbiol. 1983 Apr;2(2):111-5 PMID: 6222896
  19. In vitro and in vivo activity of DL-8280, a new oxazine derivative.
    Antimicrob Agents Chemother. 1982 Oct;22(4):548-53 PMID: 6960805
  20. Studies on the mechanism of action of nalidixic acid.
    Antimicrob Agents Chemother. 1973 Oct;4(4):479-86 PMID: 4208771
  21. Escherichia coli K-12 mutants resistant to nalidixic acid: genetic mapping and dominance studies.
    J Bacteriol. 1969 Jul;99(1):238-41 PMID: 4895844
  22. Investigations into the mechanism of action of the antibacterial agent norfloxacin.
    J Antimicrob Chemother. 1984 May;13 Suppl B:9-23 PMID: 6203890
  23. [A new synthetic antibacterial : 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1, 4-dihydroquinolin-3-carboxylic acid (1589 R.B.)].
    C R Seances Acad Sci III. 1981 Jan 5;292(1):37-40 PMID: 6786770
  24. MECHANISM OF ACTION OF NALIDIXIC ACID ON ESCHERICHIA COLI.II. INHIBITION OF DEOXYRIBONUCLEIC ACID SYNTHESIS.
    J Bacteriol. 1965 Apr;89:1068-74 PMID: 14276097
Article Info
Journal
Pharmaceutisch weekblad. Scientific edition
Abbr.
Pharm Weekbl Sci
ISSN
0167-6555
DOI
10.1007/BF01975474
Published
1986-02-21
Pages
22-5
Language
English
Region
Netherlands
NLM ID
7907992
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01975474
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2