Mammary tumorigenesis in feral Mus cervicolor popaeus.

Journal of virology ·Vol. 58 ·No. 2 ·1986-05-00 ·Pages 619-25

Escot C, Hogg E, Callahan R

Abstract

A pedigreed breeding population of feral Mus cervicolor popaeus with a high incidence of mammary tumors, arising between 6 and 14 months of age, is described. These mice were chronically infected with a type B retrovirus which is distantly related to the mouse mammary tumor virus (MMTV) of inbred strains of Mus musculus. MMTV-induced mammary tumors in inbred mice frequently (80%) contained an insertion of the viral genome into the int-1 or int-2 loci of the tumor cellular genome. These two cellular genetic loci were also altered by viral insertion in 11 of 20 M. cervicolor popaeus mammary tumor cellular DNAs tested. Results of our study of mammary tumorigenesis in feral mice demonstrate that viral-induced rearrangement and activation of the int loci are not limited to the genetic background of inbred mice selected for highly infectious MMTV and a high incidence of mammary tumors.

MeSH Terms

Animals DNA/analysis,genetics DNA, Neoplasm/analysis,genetics Genes Genes, Viral Liver/analysis Mammary Neoplasms, Experimental/genetics,microbiology Mammary Tumor Virus, Mouse/genetics Muridae/microbiology Recombination, Genetic

Chemicals

DNA, Neoplasm DNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Escot C

Hogg E

Callahan R

References (24)

24 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.58.2.619-625.1986

Published

1986-05-00

Pages

619-25

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC252952

Subset

External Links

PubMed source DOI: 10.1128/JVI.58.2.619-625.1986 PMC Full Text View journal details

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Mammary tumorigenesis in feral Mus cervicolor popaeus.

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