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PMID: 3013004 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Chromosomal assignment of the genes for human aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2.

American journal of human genetics ·Vol. 38 ·No. 5 ·1986-05-00 ·Pages 641-8

Hsu LC, Yoshida A, Mohandas T

Abstract

Chromosomal assignment of the genes for two major human aldehyde dehydrogenase isozymes, that is, cytosolic aldehyde dehydrogenase-1 (ALDH1) and mitochondrial aldehyde dehydrogenase-2 (ALDH2) were determined. Genomic DNA, isolated from a panel of mouse-human and Chinese hamster-human hybrid cell lines, was digested by restriction endonucleases and subjected to Southern blot hybridization using cDNA probes for ALDH1 and for ALDH2. Based on the distribution pattern of ALDH1 and ALDH2 in cell hybrids, ALDH1 was assigned to the long arm of human chromosome 9 and ALDH2 to chromosome 12.

MeSH Terms
Aldehyde Dehydrogenase/genetics Animals Chromosome Mapping Chromosomes, Human, 6-12 and X Cricetinae Cricetulus DNA Restriction Enzymes Humans Hybrid Cells Isoenzymes/genetics Mice Nucleic Acid Hybridization
Chemicals
Isoenzymes Aldehyde Dehydrogenase DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hsu L C
Yoshida A
Mohandas T
References (19)
19 references, click to expand
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Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1986-05-00
Pages
641-8
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1684817
Subset
IM
Grants
NIAAA NIH HHS · AA05763 · United States
External Links
PubMed source PMC Full Text View journal details
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