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PMID: 3016312 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Herpes simplex virus (HSV)-specific human T-cell clones recognize HSV glycoprotein D expressed by a recombinant vaccinia virus.

Journal of virology ·Vol. 59 ·No. 2 ·1986-08-00 ·Pages 506-9

Zarling JM, Moran PA, Lasky LA, Moss B

Abstract

Human cytotoxic T-cell (CTL) clones that lyse autologous cells infected with herpes simplex virus (HSV) type 1 or 2 were generated by stimulating lymphocytes with a recombinant vaccinia virus (recombinant vaccinia-gD-1 virus) that expresses HSV type 1 glycoprotein D (gD-1). Furthermore, CTL clones generated with HSV type 1 or with cloned gD-1 lysed autologous cells infected with the recombinant vaccinia-gD-1 virus. Our findings thus showed that gD serves as a target antigen for human CTLs and that a recombinant vaccinia-gD virus activates HSV-specific human CTL.

MeSH Terms
Antigens, Viral/genetics,immunology Cytotoxicity, Immunologic DNA, Recombinant Humans Immunity, Cellular Simplexvirus/genetics,immunology T-Lymphocytes, Cytotoxic/immunology Vaccinia virus/genetics Viral Proteins/genetics,immunology
Chemicals
Antigens, Viral DNA, Recombinant Viral Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Zarling J M
Moran P A
Lasky L A
Moss B
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27 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.59.2.506-509.1986
Published
1986-08-00
Pages
506-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC253104
Subset
IM
Grants
NIAID NIH HHS · AI 23249 · United States
External Links
PubMed source DOI: 10.1128/JVI.59.2.506-509.1986 PMC Full Text View journal details
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