Home LiteratureArticle Details
PMID: 6303950 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Protective immunization of mice with specific HSV-1 glycoproteins.

Immunology ·Vol. 49 ·No. 2 ·1983-06-00 ·Pages 343-52

Chan WL

Abstract

Two herpes simplex virus type 1 (HSV-1) antigens of apparent molecular weight 123,000 and 63,000 which are associated with the viral glycoprotein complex have been identified and purified using virus-specific monoclonal antibodies. Mice immunized with either glycoprotein showed marked resistance to challenge with virulent HSV-1. Therefore purified glycoproteins of HSV-1 free of nucleic acid can be used in protective immunization of mice against human herpes simplex type 1.

MeSH Terms
Animals Antigens, Viral/immunology,isolation & purification Fluorescent Antibody Technique Glycoproteins/immunology,isolation & purification Herpes Simplex/prevention & control Mice Mice, Inbred BALB C Mice, Inbred CBA Peptide Fragments/analysis Radioimmunoassay Simplexvirus/immunology Vaccination Viral Proteins/immunology,isolation & purification
Chemicals
Antigens, Viral Glycoproteins Peptide Fragments Viral Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Chan W L
References (31)
31 references, click to expand
  1. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
  2. Spread of herpes simplex virus in peripheral nerves.
    Acta Neuropathol. 1971;17(1):44-53 PMID: 4100319
  3. Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intra-axonal transport of infection.
    Infect Immun. 1973 Feb;7(2):272-88 PMID: 4348966
  4. A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels.
    Eur J Biochem. 1974 Jul 1;46(1):83-8 PMID: 4850204
  5. Immunological destruction of herpes simplex virus I infected cells.
    Nature. 1974 Oct 11;251(5475):542-3 PMID: 4371311
  6. Genetic and biochemical studies with herpesvirus.
    Cold Spring Harb Symp Quant Biol. 1975;39 Pt 2:717-30 PMID: 169027
  7. Latent herpes simplex virus and the nervous system,.
    Curr Top Microbiol Immunol. 1975;70:31-50 PMID: 169103
  8. Genetics of natural resistance to herpesvirus infections in mice.
    Nature. 1975 Nov 13;258(5531):152-3 PMID: 171586
  9. Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection.
    J Immunol. 1976 Jan;116(1):35-40 PMID: 173758
  10. Membrane proteins specified by herpes simplex viruses. I. Identification of four glycoprotein precursors and their products in type 1-infected cells.
    J Virol. 1976 Mar;17(3):991-1008 PMID: 176453
  11. Pathogenesis of herpes simplex virus types 1 and 2 in mice after various routes of inoculation.
    Infect Immun. 1976 Aug;14(2):571-8 PMID: 184048
  12. The covalent coupling of proteins to periodate-oxidized sephadex: a new approach to immunoadsorbent preparation.
    J Immunol Methods. 1976;12(1-2):171-81 PMID: 62811
  13. Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.
    J Biol Chem. 1977 Feb 10;252(3):1102-6 PMID: 320200
  14. Role of activated macrophages in resistance of congenitally athymic nude mice to hepatitis induced by herpes simplex virus type 2.
    Infect Immun. 1978 Mar;19(3):792-8 PMID: 205507
  15. Complement-mediated cytolysis of HSV-1 and HSV-2 infected cells: plasma membrane antigens reactive with type-specific and cross-reactive antibody.
    J Gen Virol. 1978 Aug;40(2):443-54 PMID: 211189
  16. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.
    Immunochemistry. 1978 Jul;15(7):429-36 PMID: 30693
  17. Host defenses in herpes simplex infections of the nervous system: effect of antibody on disease and viral spread.
    Infect Immun. 1979 Feb;23(2):305-11 PMID: 217828
  18. Membrane proteins specified by herpes simplex viruses. III. Role of glycoprotein VP7(B2) in virion infectivity.
    J Virol. 1979 Mar;29(3):1149-58 PMID: 221669
  19. Ocular infection with herpes simplex virus type 1: prevention of acute herpetic encephalitis by systemic administration of virus-specific antibody.
    J Infect Dis. 1979 Oct;140(4):534-40 PMID: 229174
  20. Herpes simplex virus glycoproteins: participation of individual herpes simplex virus type 1 glycoprotein antigens in immunocytolysis and their correlation with previously identified glycopolypeptides.
    J Virol. 1979 Dec;32(3):741-8 PMID: 229263
  21. Membrane proteins specified by herpes simplex viruses. V. Identification of an Fc-binding glycoprotein.
    J Virol. 1979 Dec;32(3):779-89 PMID: 229267
  22. Expression of herpesvirus-induced antigens in human cervical cancer.
    Nature. 1980 Feb 7;283(5747):591-3 PMID: 6243743
  23. Macrophage extrinsic antiviral activity during herpes simplex virus infection.
    J Gen Virol. 1980 Feb;46(2):291-300 PMID: 6247426
  24. A monoclonal antibody for large-scale purification of human leukocyte interferon.
    Nature. 1980 Jun 12;285(5765):446-50 PMID: 6157091
  25. Elution of herpes simplex virus-specific cytotoxic antibodies from squamous cell carcinoma of uterine cervix.
    Nature. 1980 Aug 7;286(5773):613-5 PMID: 6250079
  26. The involvement of herpes simplex virus type 1 glycoproteins in cell-mediated immunity.
    J Immunol. 1981 May;126(5):1655-60 PMID: 6971309
  27. Immunization against blood-stage rodent malaria using purified parasite antigens.
    Nature. 1981 Nov 26;294(5839):361-4 PMID: 7312033
  28. Purification of glycoprotein gD of herpes simplex virus types 1 and 2 by use of monoclonal antibody.
    J Virol. 1982 Mar;41(3):1099-1104 PMID: 6284965
  29. An adoptive cell transfer system for the evaluation of immunity to Herpes simplex virus in mice.
    Clin Exp Immunol. 1982 May;48(2):307-14 PMID: 7105488
  30. Protection against lethal challenge of BALB/c mice by passive transfer of monoclonal antibodies to five glycoproteins of herpes simplex virus type 2.
    Infect Immun. 1982 Sep;37(3):1132-7 PMID: 6290390
  31. THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. I. VIRUS PATHWAYS TO THE NERVOUS SYSTEM OF SUCKLING MICE DEMONSTRATED BY FLUORESCENT ANTIBODY STAINING.
    J Exp Med. 1964 Feb 1;119:343-56 PMID: 14164487
Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1983-06-00
Pages
343-52
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1454196
Subset
IM
External Links
PubMed source PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2