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PMID: 3019260 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A systematic study of host defense processes in badly injured patients.

Annals of surgery ·Vol. 204 ·No. 3 ·1986-09-00 ·Pages 282-99

Polk HC, George CD, Wellhausen SR, Cost K, Davidson PR, Regan MP, Borzotta AP

Abstract

A prospective study of factors predisposing to infection in badly injured patients has disclosed: the dominant roles of two specific parameters: monocyte antigen presenting capacity, and opsonic capacity of diluted serum; the potential value of further assessment of: the predictive value of plots of activated T-cells/total T-cells versus monocyte antigen presenting capacity, the apparent protective effect of the ability to sharply increase specific IgM in response to infection, and the apparent protective effect of cytomegalovirus (CMV) infection in the first 28 days after injury against major bacterial infection; the lack of value of analysis of other T- and B-cell subsets in such patients; and the need to clarify CMV and transfusion status with respect to interpretation of such data. The specific role of variable transfusion and of specific serum immunoglobulins will require further and more discriminating study.

MeSH Terms
Adolescent Adult Antibodies, Bacterial/analysis Antigen-Presenting Cells/immunology B-Lymphocytes/immunology Blood Transfusion Cytomegalovirus Infections/immunology Escherichia coli/immunology Female Humans Immunity, Cellular Leukocyte Count Male Middle Aged Monocytes/immunology Phagocytosis Prospective Studies Splenectomy T-Lymphocytes/immunology Wound Infection/immunology
Chemicals
Antibodies, Bacterial
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Polk H C
George C D
Wellhausen S R
Cost K
Davidson P R
Regan M P
Borzotta A P
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Article Info
Journal
Annals of surgery
Abbr.
Ann Surg
ISSN
0003-4932
Published
1986-09-00
Pages
282-99
Language
English
Region
United States
NLM ID
0372354
PMCID
PMC1251278
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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