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PMID: 6301997 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Lymphocyte subsets and natural killer cell responses during cytomegalovirus mononucleosis.

Infection and immunity ·Vol. 40 ·No. 2 ·1983-05-00 ·Pages 472-7

Rinaldo CR, Ho M, Hamoudi WH, Gui XE, DeBiasio RL

Abstract

Cell-mediated immunity in seven patients with cytomegalovirus mononucleosis was assessed by monoclonal antibody to lymphocyte subsets, lymphocyte blastogenesis, and natural killer cell activity. The patients had decreased ratios of helper (Leu 3a) to suppressor-cytotoxic (Leu 2a) T cells as compared with normal donors. Leu 2a+ T cells from the patients were uniquely sensitive to overnight culturing, which resulted in a 2.6-fold increase in the helper/suppressor cell ratio and the appearance of an unusual third Leu 1+ 2a- 3a- T cell subset. This correlated directly with enhanced blastogenesis to concanavalin A after preculture. Base-line and interferon-boosted natural killer cell responses versus K562 cell targets during cytomegalovirus mononucleosis did not differ from those of normal donors. This suggests that certain cellular immune functions are depressed during cytomegalovirus mononucleosis in correlation with the emergence of a culture-sensitive subset of suppressor T cells. In contrast, cytotoxic lymphocytes appear to function normally and may aid in the resolution of the illness.

MeSH Terms
Adult Antigens, Surface/analysis Cytomegalovirus Infections/immunology Female Humans Immune Tolerance Infectious Mononucleosis/immunology Killer Cells, Natural/immunology Lymphocytes/classification Male Middle Aged T-Lymphocytes, Regulatory/immunology
Chemicals
Antigens, Surface
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Rinaldo C R
Ho M
Hamoudi W H
Gui X E
DeBiasio R L
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30 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.40.2.472-477.1983
Published
1983-05-00
Pages
472-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC264879
Subset
IM
Grants
NIAID NIH HHS · AI-16212 · United States
External Links
PubMed source DOI: 10.1128/iai.40.2.472-477.1983 PMC Full Text View journal details
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