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PMID: 3019676 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

A new homeo-box is present in overlapping cosmid clones which define the mouse Hox-1 locus.

The EMBO journal ·Vol. 5 ·No. 8 ·1986-08-00 ·Pages 1973-80

Duboule D, Baron A, Mähl P, Galliot B

Abstract

A new murine homeo-box (Hox1-3) has been isolated and studied with respect to its structure and transcriptional pattern. This homeo-box is part of a gene which is specifically regulated during mouse prenatal development and expressed in a restricted number of teratocarcinoma tumours as well as in adult testis. Hox1-3 is shown to be a member of a cluster of at least four homeo-boxes lying within a 75-kb segment of DNA on mouse chromosome 6. The structure of the whole cluster, the Hox-1 locus is presented.

MeSH Terms
Animals Base Sequence Cloning, Molecular Cosmids DNA Restriction Enzymes Drosophila/genetics Embryo, Mammalian Embryo, Nonmammalian Female Fetus Humans Mice Mice, Inbred Strains Nucleic Acid Hybridization Pregnancy Sequence Homology, Nucleic Acid Species Specificity Teratoma/genetics Transcription, Genetic Xenopus
Chemicals
DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Duboule D
Baron A
Mähl P
Galliot B
References (36)
36 references, click to expand
  1. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
    J Mol Biol. 1977 Jun 15;113(1):237-51 PMID: 881736
  2. Teratocarcinomas and mammalian embryogenesis.
    Science. 1980 Aug 15;209(4458):768-76 PMID: 6250214
  3. The development of transplantable teratocarcinomas from intratesticular grafts of pre- and postimplantation mouse embryos.
    Dev Biol. 1970 Mar;21(3):364-82 PMID: 5436899
  4. Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.
    Cell. 1985 Nov;43(1):19-28 PMID: 4075393
  5. Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins.
    Nature. 1984 Jul 5-11;310(5972):25-31 PMID: 6330566
  6. The homeo box and mammalian development.
    Cell. 1985 Nov;43(1):1-2 PMID: 3907850
  7. Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts.
    Nature. 1985 Jan 24-30;313(6000):284-9 PMID: 2481829
  8. Teratomas and chimeras.
    Sci Am. 1979 Apr;240(4):120-32 PMID: 451528
  9. The homeo box: a key to the understanding of development?
    Cell. 1985 Jan;40(1):3-5 PMID: 3967292
  10. Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus.
    Cell. 1985 Nov;43(1):9-18 PMID: 3000607
  11. Viral enhancer activity in teratocarcinoma cells.
    Cold Spring Harb Symp Quant Biol. 1985;50:747-52 PMID: 3007013
  12. Cloning of an X. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes.
    Cell. 1984 Jun;37(2):409-14 PMID: 6327066
  13. Mutations affecting segment number and polarity in Drosophila.
    Nature. 1980 Oct 30;287(5785):795-801 PMID: 6776413
  14. The elements of the bithorax complex.
    Cell. 1983 Dec;35(3 Pt 2):595-601 PMID: 6418387
  15. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.
    Eur J Biochem. 1980 Jun;107(2):303-14 PMID: 6772444
  16. A system for shotgun DNA sequencing.
    Nucleic Acids Res. 1981 Jan 24;9(2):309-21 PMID: 6259625
  17. Selective isolation of cosmid clones by homologous recombination in Escherichia coli.
    Proc Natl Acad Sci U S A. 1984 Jul;81(13):4129-33 PMID: 6330743
  18. Fly and frog homoeo domains show homologies with yeast mating type regulatory proteins.
    Nature. 1984 Jul 5-11;310(5972):70-1 PMID: 6429549
  19. Structural analysis of murine genes containing homoeo box sequences and their expression in embryonal carcinoma cells.
    Nature. 1985 Apr 25-May 1;314(6013):713-8 PMID: 2986010
  20. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans.
    Cell. 1984 Jun;37(2):403-8 PMID: 6327065
  21. A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes.
    Nature. 1984 Mar 29-Apr 4;308(5958):428-33 PMID: 6323992
  22. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  23. DNA sequencing with chain-terminating inhibitors.
    Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 PMID: 271968
  24. Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.
    Cell. 1984 Oct;38(3):667-73 PMID: 6091895
  25. A gene complex controlling segmentation in Drosophila.
    Nature. 1978 Dec 7;276(5688):565-70 PMID: 103000
  26. Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes.
    Nucleic Acids Res. 1985 Feb 11;13(3):711-26 PMID: 3873645
  27. A homeo-box-containing gene expressed during oogenesis in Xenopus.
    Cell. 1984 Nov;39(1):157-62 PMID: 6207937
  28. Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.
    Proc Natl Acad Sci U S A. 1978 Oct;75(10):4853-7 PMID: 283395
  29. Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila.
    Cell. 1984 Oct;38(3):675-80 PMID: 6091896
  30. Cloning of the homeotic Sex combs reduced gene in Drosophila and in situ localization of its transcripts.
    EMBO J. 1985 Dec 30;4(13B):3757-64 PMID: 16453653
  31. A mouse homoeo box gene is expressed during embryogenesis and in adult kidney.
    Nature. 1985 Oct 24-30;317(6039):745-8 PMID: 4058581
  32. Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene.
    Cell. 1985 Nov;43(1):29-37 PMID: 2416459
  33. Clustered homeo boxes are differentially expressed during murine development.
    Cell. 1985 Nov;43(1):39-45 PMID: 2416462
  34. A new method for sequencing DNA.
    Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4 PMID: 265521
  35. Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes.
    Nature. 1985 Mar 14-20;314(6007):175-8 PMID: 4038785
  36. Comparative chromosome mapping of a conserved homoeo box region in mouse and human.
    Nature. 1985 Mar 14-20;314(6007):173-5 PMID: 3919316
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1986-08-00
Pages
1973-80
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1167066
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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