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PMID: 3022536 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Pick body-like inclusions in the dentate fascia of the hippocampus in Alzheimer's disease.

Acta neuropathologica ·Vol. 71 ·No. 1-2 ·1986-00-00 ·Pages 38-45

Dickson DW, Yen SH, Horoupian DS

Abstract

Pick body-like inclusions are described in the granular neurons of the dentate fascia in Alzheimer's disease. The inclusions are round, argyrophilic and stained by thioflavine-S. Immunocytochemically they contain antigenic determinants of neurofilaments and of Alzheimer neurofibrillary tangles. Ultrastructurally they are composed primarily of 15-18 nm straight filaments similar to the neurofibrillary pathology of progressive supranuclear palsy and Pick's disease. The dentate fascia inclusions, as well as cerebellar plaques but not amyloid angiopathy, are found most frequently in association with severe neurofibrillary degeneration.

MeSH Terms
Aged Aged, 80 and over Alzheimer Disease/metabolism,pathology Hippocampus/metabolism,ultrastructure Humans Inclusion Bodies/metabolism,ultrastructure Intermediate Filament Proteins/metabolism Microscopy, Electron Middle Aged Neurofibrils/metabolism,pathology
Chemicals
Intermediate Filament Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dickson D W
Yen S H
Horoupian D S
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00687960
Published
1986-00-00
Pages
38-45
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
Grants
NIA NIH HHS · AG 01136 · United States
NIA NIH HHS · AG 04145 · United States
External Links
PubMed source DOI: 10.1007/BF00687960 View journal details
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