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PMID: 7257733 Published · ppublish English Journal Article

Reappraisal of the fine structure of Alzheimer's neurofibrillary tangles.

Acta neuropathologica ·Vol. 54 ·No. 3 ·1981-00-00 ·Pages 239-46

Yagishita S, Itoh Y, Nan W, Amano N

Abstract

Alzheimer's neurofibrillary tangles were studied by electron microscopy. The study includes four cases of Alzheimer's disease, two cases of atypical senile dementia, and one case of progressive supranuclear palsy. In Alzheimer's disease the tangles were composed of either straight filaments or paired helical filaments. In progressive supranuclear palsy the tangles were composed of 15 nm straight filaments or helical filaments. A few straight filaments were mixed with paired helical filaments. In atypical senile dementia, both straight and paired helical filaments comprised the tangles and one type of filaments appeared to intermingle with the other in the same neurons.

MeSH Terms
Adult Aged Alzheimer Disease/pathology Brain/ultrastructure Brain Diseases/pathology Dementia/pathology Female Humans Male Microscopy, Electron Middle Aged
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yagishita S
Itoh Y
Nan W
Amano N
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25 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00687747
Published
1981-00-00
Pages
239-46
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00687747 View journal details
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