Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers.

The Journal of experimental medicine ·Vol. 146 ·No. 4 ·1977-10-01 ·Pages 1138-42

Mond JJ, Lieberman R, Inman JK, Mosier DE, Paul WE

Abstract

Mice with the CBA/N defect are unresponsive to the hapten phosphorylcholine (PC) even when presented on a variety of immunogenic carriers. Since these mice have the variable region gene for PC, their inability to respond may reflect deletion or suppression of the line of B lymphocytes which is responsible for the anti-PC response.

MeSH Terms

Animals B-Lymphocytes/immunology Carrier Proteins/immunology Choline/analogs & derivatives Female Genes Genetic Linkage Haptens Immunoglobulin Allotypes Male Mice Mice, Inbred BALB C/immunology Mice, Inbred CBA/immunology Mice, Inbred DBA/immunology Phosphorylcholine/immunology Sex Chromosomes Spleen/immunology

Chemicals

Carrier Proteins Haptens Immunoglobulin Allotypes Phosphorylcholine Choline

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Mond J J

Lieberman R

Inman J K

Mosier D E

Paul W E

References (14)

14 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.146.4.1138

Published

1977-10-01

Pages

1138-42

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2180827

Subset

External Links

PubMed source DOI: 10.1084/jem.146.4.1138 PMC Full Text View journal details

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Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers.

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