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PMID: 3024114 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The DNA replication origins of herpes simplex virus type 1 strain Angelotti.

Nucleic acids research ·Vol. 14 ·No. 21 ·1986-11-11 ·Pages 8655-67

Knopf CW, Spies B, Kaerner HC

Abstract

The nucleotide sequences of the origins of DNA replication (ori) of the S- and L-component (oriS, oriL) of the herpes simplex virus type 1 (HSV-1) standard genome were determined from HSV-1 strain Angelotti (ANG). In contrast to other HSV-1 strains, the ANG oriS sequence revealed an insertion of an TA-dinucleotide in an otherwise very conserved but imperfect palindromic sequence of 47 bp. The oriL sequence of the standard ANG genome was found to be identical to that of an ANG class II defective genome which exhibits a duplication of a 144 bp palindrome. A model is presented to explain the origination of the amplified ANG oriL sequences from the parental genome with a single copy of oriL via illegitimate recombination. Alignment of the ori sequences of HSV, adeno- and papovaviruses unveiled that the HSV ori region can be subdivided into two distinct sites of homology to the DNA initiation signals of papova- and adenoviruses, suggesting that the HSV origins of replication comprise elements for DNA replication by both, cellular and virus-encoded DNA polymerases.

MeSH Terms
Animals Base Sequence Cell Line Chlorocebus aethiops Cloning, Molecular DNA Replication Genes, Viral Kidney Nucleic Acid Conformation Simplexvirus/genetics
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Knopf C W
Spies B
Kaerner H C
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48 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/14.21.8655
Published
1986-11-11
Pages
8655-67
Language
English
Region
England
NLM ID
0411011
PMCID
PMC311884
Subset
IM
Databases
GENBANK
X04589, X04597
External Links
PubMed source DOI: 10.1093/nar/14.21.8655 PMC Full Text View journal details
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